Title: Flurothyl
CAS Registry Number: 333-36-8
CAS Name: 1,1¢-Oxybis[2,2,2-trifluoroethane]
Additional Names: bis(2,2,2-trifluoroethyl) ether; hexafluorodiethyl ether; bis(trifluoroethyl) ether
Trademarks: Indoklon (Ohio Med.)
Molecular Formula: C4H4F6O
Molecular Weight: 182.06
Percent Composition: C 26.39%, H 2.21%, F 62.61%, O 8.79%
Line Formula: CF3CH2OCH2CF3
Literature References: Prepn: GB 814493 (1959 to Pennsalt Chem.); GB 889282 (1962 to Air Reduction). Toxicology in animals: A. Cherkin, Psychopharmacologia 15, 404 (1969). Review of pharmacology: L. Arce, Psychosomatics 11, 358-360 (1970); of clinical trials in psychiatric convulsant therapy: J. G. Small, I. F. Small, Semin. Psychiatry 4, 13-26 (1972).
Properties: Colorless, mobile liq, mild ethereal, pleasant odor. d420 1.41. bp 63.9°. Practically insol in water. Sol in alcohol.
Boiling point: bp 63.9°
Density: d420 1.41
Therap-Cat: CNS stimulant.
Keywords: CNS Stimulant.
Fluroxene Fluroxypyr Flurprimidol Flurtamone Flusilazole

Systematic (IUPAC) name
bis(2,2,2-trifluoroethyl) ether
Clinical data
Legal status  ?
CAS number 333-36-8 YesY
ATC code None
PubChem CID 9528
Synonyms Hexafluorodiethyl ether
Chemical data
Formula C4H4F6O 
Mol. mass 182.064
Physical data
Density 1.404 g/cm3 g/cm³
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Flurothyl (Indoklon) is a volatile liquid drug from the halogenated ether family, related to inhaled anaesthetic agents such as diethyl ether, but having the opposite effects, acting as a stimulant and convulsant.[1] Several compounds related to the halogenated ether anesthetics have similar convulsant effects rather than producing sedation, and this has been helpful in studying the mechanism of action of these drugs.[2][3][4] Flurothyl was previously used in psychiatric medicine for shock therapy, in a similar manner to other convulsant drugs such as pentetrazol, as an alternative to electroconvulsive therapy.[5][6] This use has now been discontinued, but it is still widely used in scientific research for inducing seizures in animals.[7]

See also: Theories of general anaesthetic action.