Title: Flutrimazole
CAS Registry Number: 119006-77-8
CAS Name: 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole
Additional Names: 1-[o-fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole
Manufacturers' Codes: UR-4056
Trademarks: Micetal (Uriach)
Molecular Formula: C22H16F2N2
Molecular Weight: 346.37
Percent Composition: C 76.29%, H 4.66%, F 10.97%, N 8.09%
Literature References: Prepn: J. Bartroli, M. Anguita, EP 352352; eidem, US 5149707 (1990, 1992 both to Uriach). Series of articles on synthesis, antifungal activity, pharmacokinetics: Arzneim.-Forsch. 42, 832-863 (1992). Toxicity study: M. L. Vericat et al., ibid. 841. Clinical trial in dermatomycoses: O. Binet et al., Mycoses 37, 455 (1994).
Properties: Crystals from acetonitrile, mp 164-167°. Also reported as white solid, mp 161-163°. LD50 in male, female mice, male, female rats (mg/kg): >1000, >1000, 808, 1214 orally; >2000, >2000, 1079, 1446 i.p. (Vericat).
Melting point: mp 164-167°; mp 161-163°
Toxicity data: LD50 in male, female mice, male, female rats (mg/kg): >1000, >1000, 808, 1214 orally; >2000, >2000, 1079, 1446 i.p. (Vericat)
Therap-Cat: Antifungal (topical).
Keywords: Antifungal (Synthetic); Imidazoles.
Flutropium Bromide Fluvalinate Fluvastatin Fluvoxamine FM1-43

Systematic (IUPAC) name
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
CAS number 119006-77-8
ATC code D01AC16 G01AF18
PubChem CID 3401
ChemSpider 3284 YesY
UNII 776S0UP252 YesY
KEGG D07193 YesY
Chemical data
Formula C22H16F2N2 
Mol. mass 346.373 g/mol
 YesY (what is this?)  (verify)

Flutrimazole is a wide spectrum antifungal drug. It is used for the topical treatment of superficial mycoses of the skin. Flutrimazole is an imidazole derivative. It interferes with the synthesis of ergosterol by inhibiting the activity of the enzyme lanosterol-14-demethylase.