Fonazine

Title: Fonazine
CAS Registry Number: 7456-24-8
CAS Name: 10-[2-(Dimethylamino)propyl]-N,N-dimethyl-10H-phenothiazine-2-sulfonamide
Additional Names: 10-(2-dimethylaminopropyl)-3-dimethylsulfamidophenothiazine; 3-dimethylsulfamido-10-(2-dimethylaminopropyl)phenothiazine; dimethothiazine; dimethiotazine; dimetiotazine
Manufacturers' Codes: RP-8599
Molecular Formula: C19H25N3O2S2
Molecular Weight: 391.55
Percent Composition: C 58.28%, H 6.44%, N 10.73%, O 8.17%, S 16.38%
Literature References: Serotonin inhibitor. Prepn: GB 814512 (1959 to Rhône-Poulenc). Pharmacokinetics and distribution in dog and rat: O. R. W. Lewellen, R. Templeton, Adv. Biochem. Psychopharmacol. 9, 213 (1974). Clinical evaluation in spasticity: W. B. Matthews et al., Acta Neurol. Scand. 48, 635 (1972). HPLC determn in plasma: J. Holt et al., Br. J. Clin. Pharmacol. 13, 282 (1982).
Derivative Type: Hydrochloride
Molecular Formula: C19H25N3O2S2.HCl
Molecular Weight: 428.01
Percent Composition: C 53.32%, H 6.12%, N 9.82%, O 7.48%, S 14.98%, Cl 8.28%
Properties: Crystals, dec 214°.
Derivative Type: Methanesulfonate
CAS Registry Number: 7455-39-2
Additional Names: Dimethothiazine mesylate; fonazine mesylate
Trademarks: Banistyl (M & B); Bonpac (Hoei); Calsekin (Mect); Migristène (Specia); Neomestine (Taiyo); Promaquid (Rh>e-Poulenc); Yoristen (Kodama)
Molecular Formula: C19H25N3O2S2.CH3SO3H
Molecular Weight: 487.66
Percent Composition: C 49.26%, H 5.99%, N 8.62%, O 16.40%, S 19.73%
Therap-Cat: Antimigraine.
Keywords: Antimigraine.
Fondaparinux Sodium Fonofos Foramsulfuron Formaldehyde Formaldehyde Sodium Bisulfite