Fospropofol

Title: Fospropofol
CAS Registry Number: 258516-89-1
CAS Name: [2,6-Bis(1-methylethyl)phenoxy]methanol dihydrogen phosphate
Additional Names: phosphono-O-methyl-2,6-diisopropylphenol
Molecular Formula: C13H21O5P
Molecular Weight: 288.28
Percent Composition: C 54.16%, H 7.34%, O 27.75%, P 10.74%
Literature References: Prodrug of propofol, q.v. Prepn: V. J. Stella et al., WO 0008033; eidem, US 6204257 (2000, 2001 to Univ. Kansas). Clinical pharmacokinetics and pharmacodynamics: J. Fechner et al., Anesthesiology 99, 303 (2003). Clinical evaluation to induce and maintain sedation: eidem, Anesth. Analg. 100, 701 (2005). Clinical comparison with propofol: E. Gibiansky et al., Anesthesiology 103, 718 (2005); M. M. R. Struys et al., ibid. 730. Review: M. D. Krasowski, Curr. Opin. Invest. Drugs 6, 90-98 (2005).
Properties: Colorless oil, unstable on standing at room temp.
Derivative Type: Disodium salt
CAS Registry Number: 258516-87-9
Additional Names: Fospropofol disodium
Manufacturers' Codes: GPI-15715
Trademarks: Aquavan (Guilford)
Molecular Formula: C13H19Na2O5P
Molecular Weight: 332.24
Percent Composition: C 47.00%, H 5.76%, Na 13.84%, O 24.08%, P 9.32%
Properties: White powder. Sol in water.
Therap-Cat: Anesthetic (intravenous).
Keywords: Anesthetic (Intravenous).
Fosthiazate Fosthietan Fotemustine Frangula Frangulin

Fospropofol
Fospropofol disodium.svg
Systematic (IUPAC) name
disodium [2,6-di(propan-2-yl)phenoxy]methyl phosphate[1]
Clinical data
AHFS/Drugs.com monograph
Licence data US FDA:link
Pregnancy cat. B
Legal status Schedule IV (US)
Dependence liability unknown
Routes Intravenous
Pharmacokinetic data
Protein binding 98%[2]
Metabolism Hepatic glucuronidation
Half-life 0.81 hours[2]
Excretion Renal
Identifiers
CAS number 258516-87-9 YesY
ATC code N01
PubChem CID 3038497
DrugBank DB06716
UNII LZ257RZP7K N
KEGG D04257 YesY
ChEMBL CHEMBL1201766 N
Chemical data
Formula C13H19Na2O5P 
Mol. mass 332.240261 g/mol[1]
 N (what is this?)  (verify)

Fospropofol (trade name Lusedra[3]) is an intravenous sedative-hypnotic agent. It is currently approved for use in sedation of adult patients undergoing diagnostic or therapeutic procedures such as endoscopy.