Furazolidone

Title: Furazolidone
CAS Registry Number: 67-45-8
CAS Name: 3-[[(5-Nitro-2-furanyl)methylene]amino]-2-oxazolidinone
Additional Names: 3-(5-nitrofurfurylideneamino)-2-oxazolidinone; N-(5-nitro-2-furfurylidene)-3-amino-2-oxazolidone
Manufacturers' Codes: NF-180
Trademarks: Furovag; Furoxane; Furoxone (Eaton); Giarlam; Giardil; Medaron; Neftin; Nicolen; Nifulidone; Ortazol; Roptazol; Tikofuran; Topazone
Molecular Formula: C8H7N3O5
Molecular Weight: 225.16
Percent Composition: C 42.67%, H 3.13%, N 18.66%, O 35.53%
Literature References: Prepn: GB 735136; G. Gever, US 2742462; G. D. Drake et al., US 2759931; G. Gever, C. J. O'Keefe, US 2927110 (1955, 1956, 1956, 1960 all to Norwich); G. Gever et al., J. Am. Chem. Soc. 77, 2277 (1955). LC-MS/MS determn of residues in meat: P. Mottier et al., J. Chromatogr. A 1067, 85 (2005). Antimicrobial spectrum and toxicity: J. A. Yurchenco et al., Antibiot. Chemother. 3, 1035 (1953); G. S. Rogers et al., ibid. 6, 231 (1956). Pharmacology and toxicology: B. H. Ali, Vet. Res. Commun. 6, 1 (1983).
Properties: Yellow crystals from DMF, mp 256-257°. Darkens under strong light. Soly in water (pH 6): approx 40 mg/l. Dec by alkali.
Melting point: mp 256-257°
Therap-Cat: Anti-infective (topical); topical antiprotozoal (Trichmonas).
Therap-Cat-Vet: Antimicrobial.
Keywords: Antiprotozoal (Trichomonas); Antiseptic/Disinfectant; Nitrofurans.
Furazolium Chloride Furcellaran Furethidine Furfural Furfuryl Alcohol

Furazolidone
Furazolidone.svg
Furazolidone ball-and-stick.png
Systematic (IUPAC) name
3-{[(5-nitro-2-furyl)methylene]amino}-1,3-oxazolidin-2-one
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Legal status  ?
Routes Oral-Local
Identifiers
CAS number 67-45-8 YesY
ATC code G01AX06 QJ01XE90
PubChem CID 3435
DrugBank DB00614
ChemSpider 3317 YesY
UNII 5J9CPU3RE0 YesY
KEGG C07999 N
ChEMBL CHEMBL1103 N
Chemical data
Formula C8H7N3O5 
Mol. mass 225.16
 N (what is this?)  (verify)

Furazolidone is a nitrofuran antibacterial. It is marketed by Roberts Laboratories under the brand name Furoxone and by GlaxoSmithKline as Dependal-M.