Title: Fusafungine
CAS Registry Number: 1393-87-9
Manufacturers' Codes: S-314
Trademarks: Biofusal; Fusaloyos; Fusarine; Locabiotal (Servier)
Literature References: Antibiotic used as an aerosol for local application. Isoln from Fusarium species: Couchoud, FR 1164181 (1958), C.A. 54, 20074b (1960); Servier, BE 612474 (1962), C.A. 57, 11320b (1962); idem, GB 1018626 (1966 to Biofarma), C.A. 64, 16585b (1966). Bacteriological activity: D. Haler, J. Int. Med. Res. 5, 61 (1977); idem, Vie Med. 61, 507 (1980).
Properties: Solid, mp 125-129°. Stable up to 180°. Practically insol in water. Sol in glycols and fats.
Melting point: mp 125-129°
Therap-Cat: Antibacterial.
Keywords: Antibacterial (Antibiotics); Polypeptides.
Fusaric Acid Fusarubin Fuscin Fusel Oil Fusidic Acid

Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
CAS number 1393-87-9 YesY
ATC code R02AB03
UNII 65DD690W0C YesY
KEGG D08002 N
Synonyms Fusafungin
Chemical data
Formula C29H51N2O8 
Mol. mass 555.72 g/mol[1]
 N (what is this?)  (verify)

Fusafungine (INN), also known as fusafungin, is an active agent used in antibiotics for treatment of nasal and throat infection. It also possesses anti-inflammatory properties. Fusafungine is a mixture of enniatin cyclohexadepsipeptides made up of alternating D-α-hydroxyvaleric acid and L-N-methylamino acid residues,[2] produced by the ascomycete Fusarium lateritium, and marketed by Servier under the trade names Locabiotal, Bioparox, and Locabiosol.

According to a pooled analysis study done in the UK for the efficacy of fusafungine in rhinopharingitis, it was found that the proportion of patients who showed an improvement in symptoms from Day 0 to Day 4 of infection was 61.5% with fusafungine vs. 46.8% when compared to a placebo. [3]