GDNF

Title: GDNF
Additional Names: Glial cell line-derived neurotrophic factor
Literature References: Survival factor for dopaminergic neurons and spinal motoneurons. Prototype of a family of neurotrophic factors known as GDNF family ligands (GFL) which also includes neurturin, persephin, and artemin. Glycosylated, disulfide-linked homodimer; mol wt 40-45 kDa; structurally related to the TGF-b superfamily. Widely expressed in peripheral tissues and brain during embryonic and early postnatal development. Isoln from rat glial cells and prepn of recombinant human form: L. H. Lin et al., Science 260, 1130 (1993). Review of pharmacology and therapeutic potential: P. A. Lapchak, Rev. Neurosci. 7, 165-176 (1996); of neuroprotective and neurorestorative properties: D. M. Gash et al., Ann. Neurol. 44, Suppl. 1, S121-S125 (1998). Analgesic effect in neuropathic pain models: T. J. Boucher et al., Science 290, 124 (2000). Reviews: M. C. Bohn et al., Int. J. Dev. Neurosci. 18, 679-684 (2000); M. S. Airaksinen, M. Saarma, Nat. Rev. Neurosci.. 3, 383-394 (2002).
Derivative Type: Liatermin
CAS Registry Number: 188630-14-0
CAS Name: Methionyl neurotrophic factor (human glial-derived), dimer
Literature References: Production in E. coli by recombinant DNA technology: L. H. Lin et al., US 6093802 (2000 to Amgen). Clinical evaluation in Parkinson's disease: S. S. Gill et al., Nat. Med. 9, 589 (2003).
Gefarnate Geissoschizoline Geissospermine Gellan Gum Gelsemium

Glial cell derived neurotrophic factor

GDNF structure
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols GDNF (; ATF1; ATF2; HFB1-GDNF; HSCR3)
External IDs OMIM: 600837 MGI: 107430 HomoloGene: 433 GeneCards: GDNF Gene
RNA expression pattern
PBB GE GDNF 221359 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 2668 14573
Ensembl ENSG00000168621 ENSMUSG00000022144
UniProt P39905 P48540
RefSeq (mRNA) NM_000514 NM_010275
RefSeq (protein) NP_000505 NP_034405
Location (UCSC) Chr 5:
37.81 – 37.84 Mb
Chr 15:
7.81 – 7.84 Mb
PubMed search [1] [2]

Glial cell-derived neurotrophic factor, also known as GDNF is a protein that, in humans, is encoded by the GDNF gene.[1] GDNF is a small protein that potently promotes the survival of many types of neurons.[2]