Gemfibrozil

Title: Gemfibrozil
CAS Registry Number: 25812-30-0
CAS Name: 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic acid
Additional Names: 2,2-dimethyl-5-(2,5-xylyloxy)valeric acid
Manufacturers' Codes: CI-719
Trademarks: Decrelip (Ferrer); Genlip (Teofarma); Gevilon (Pfizer); Lipozid (Pfizer); Lipur (Pfizer); Lopid (Pfizer)
Molecular Formula: C15H22O3
Molecular Weight: 250.33
Percent Composition: C 71.97%, H 8.86%, O 19.17%
Literature References: Serum lipid regulating agent. Prepn: P. L. Creger, DE 1925423; eidem, US 3674836 (1969, 1972, both to Parke, Davis). Production: O. P. Goel, US 4126637 (1978 to Warner-Lambert). Pharmacology: A. H. Kissebach et al., Atherosclerosis 24, 199 (1976); M. T. Kahonen et al., ibid. 32, 47 (1979). Series of articles on metabolism, clinical pharmacology, kinetics and toxicology: Proc. R. Soc. Med. 69, Suppl 2, 1-120 (1976). Toxicity data: S. M. Kurtz et al., ibid. 15. Clinical trial in hyperlipidemia: J. E. Lewis et al., Pract. Cardiol. 9, 99 (1983). Clinical reduction of cardiovascular risk in patients with low HDL levels: H. B. Rubins et al., N. Engl. J. Med. 341, 410 (1999).
Properties: Crystals from hexane, mp 61-63°. bp0.02 158-159°. LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz).
Melting point: mp 61-63°
Boiling point: bp0.02 158-159°
Toxicity data: LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)
Therap-Cat: Antilipemic.
Keywords: Antilipemic; Fibrates.
Gemifloxacin Gemtuzumab Ozogamicin Genite? Gentamicin Gentianine

Gemfibrozil
Gemfibrozil.svg
Systematic (IUPAC) name
5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoic acid
Clinical data
Trade names Lopid
AHFS/Drugs.com monograph
MedlinePlus a686002
Pregnancy cat. Category C
Legal status By Prescription
Routes Oral
Pharmacokinetic data
Bioavailability Close to 100%
Protein binding 95%
Metabolism Hepatic (CYP3A4)
Half-life 1.5 hours
Excretion Renal 94%
Feces 6%
Identifiers
CAS number 25812-30-0 YesY
ATC code C10AB04
PubChem CID 3463
IUPHAR ligand 3439
DrugBank DB01241
ChemSpider 3345 YesY
UNII Q8X02027X3 YesY
KEGG D00334 YesY
ChEBI CHEBI:5296 YesY
ChEMBL CHEMBL457 YesY
Chemical data
Formula C15H22O3 
Mol. mass 250.333 g/mol
 YesY (what is this?)  (verify)

Gemfibrozil is the generic name for an oral drug used to lower lipid levels. It belongs to a group of drugs known as fibrates. It is most commonly sold as the brand name, Lopid. Other brand names include Jezil and Gen-Fibro.[citation needed]