Title: Gestodene
CAS Registry Number: 60282-87-3
CAS Name: (17a)-13-Ethyl-17-hydroxy-18,19-dinorpregna-4,15-dien-20-yn-3-one
Additional Names: 17a-ethynyl-17b-hydroxy-18-methyl-4,15-estradien-3-one; 17a-ethynyl-13-ethyl-17b-hydroxy-4,15-gonadien-3-one
Manufacturers' Codes: SH B 331
Molecular Formula: C21H26O2
Molecular Weight: 310.43
Percent Composition: C 81.25%, H 8.44%, O 10.31%
Literature References: Orally active gestogen with progesterone-like profile of activity. Prepn: BE 847090; H. Hofmeister et al., US 4081537 (1977, 1978 both to Schering AG). Pharmacokinetics: B. Duesterberg et al., Contraception 24, 673 (1981); B. Duesterberg, Steroids 43, 43 (1984). Comparative study of anti-aldosterone activity: W. Losert et al., Arzneim.-Forsch. 35, 459 (1985). Clinical trial as oral contraceptive: G. Hoppe, Adv. Contracept. 3, 159 (1987).
Properties: Crystals from acetone-hexane, mp 197.9°.
Melting point: mp 197.9°
Derivative Type: Mixture with ethinyl estradiol
CAS Registry Number: 109852-02-0
Trademarks: Femodene (Schering AG); Femovan (Schering AG); Ginoden (Schering AG); Gynera (Schering AG); Harmonet (Wyeth); Meliane (Schering AG); Milvane (Schering AG); Minulet (Wyeth); Phaeva (Schering AG); Tri-Minulet (Wyeth)
Therap-Cat: Progestogen. In combination with estrogen as oral contraceptive.
Keywords: Contraceptive (Oral); Progestogen.
Gestonorone Caproate Gestrinone Ghatti Gum Ghi Gibberellic Acid

Systematic (IUPAC) name
Clinical data
AHFS/ International Drug Names
Pregnancy cat. X
Legal status Prescription only
Routes oral administration
Pharmacokinetic data
Bioavailability in vitro 99% using 3H=R5020 / in vivo similar to progesterone
Half-life 16 to 18 hrs.
Excretion urinary tract mainly
CAS number 60282-87-3 YesY
ATC code G03AA10 G03AB06 (only combinations with estrogens)
PubChem CID 3033968
DrugBank DB06730
ChemSpider 2298532 YesY
UNII 1664P6E6MI YesY
KEGG D04316 YesY
Chemical data
Formula C21H26O2 
Mol. mass 310.430 g/mol
 YesY (what is this?)  (verify)

Gestodene is a progestogen hormonal contraceptive. Products containing gestodene include:

  • Melodene-15, Mirelle, and Minesse which contain 15 mcg of ethinylestradiol and 60 mcg of gestodene;
  • Meliane, Sunya, Femodette, and Millinette 20/75 which contain 20 mcg of ethinylestradiol and 75 mcg of gestodene; and
  • Gynera, Minulet, Femoden, Femodene, Katya and Millinette 30/75 which contain 30 mcg of ethinylestradiol and 75 mcg of gestodene.[1]