Giractide

Title: Giractide
CAS Registry Number: 24870-04-0
CAS Name: 1-Glycine-18-L-argininamide-a(1-18)-corticotropin
Molecular Formula: C100H156N34O22S
Molecular Weight: 2218.59
Percent Composition: C 54.14%, H 7.09%, N 21.47%, O 15.87%, S 1.45%
Literature References: Polypeptide corresp to the first 18 amino acid residues in corticotropin, in which the 1-serine is replaced by glycine. Prepn: H. Otsuka et al., Bull. Chem. Soc. Jpn. 43, 196 (1970); of the hexaacetate: eidem, JP 70 19061 (1970 to Shionogi), C.A. 73, 110138r (1970). Adrenocorticotropic potency in man: J. Clin. Endocrinol. Metab. 33, 355 (1971). Fluorometric study: T. Muraki et al., Experientia 32, 1605 (1976). Absorption: M. Hirata et al., Chem. Pharm. Bull. 26, 1061 (1978). Chromatographic studies: S. Terabe et al., J. Chromatogr. 172, 163 (1979); M. Schoeneshoefer, A. Fenner, ibid. 224, 472 (1981).
Properties: [a]D23.5 -51.4 ±1.9° (c = 0.472 in 0.1N acetic acid). uv max (0.1N NaOH): 281, 288 nm (e 6750, 6490).
Optical Rotation: [a]D23.5 -51.4 ±1.9° (c = 0.472 in 0.1N acetic acid)
Absorption maximum: uv max (0.1N NaOH): 281, 288 nm (e 6750, 6490)
Derivative Type: Hexaacetate salt
CAS Registry Number: 29365-11-5
Manufacturers' Codes: S-50022
Trademarks: Acthormon (Shionogi)
Molecular Formula: C100H156N34O22S.6C2H4O2
Molecular Weight: 2578.90
Percent Composition: C 52.16%, H 7.04%, N 18.47%, O 21.09%, S 1.24%
Therap-Cat: Adrenocorticotropic hormone.
Keywords: Adrenocorticotropic Hormone.
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