Glibornuride

Title: Glibornuride
CAS Registry Number: 26944-48-9
CAS Name: [1S-(endo,endo)]-N-[[(3-Hydroxy-4,7,7-trimethylbicyclo[2.2.1]hept-2-yl)amino]carbonyl]-4-methylbenzenesulfonamide
Additional Names: (1R,2R,3S,4S)-1-(2-hydroxy-3-bornyl)-3-(p-tolylsulfonyl)urea; D-3-endo-p-tosylureidoborneol; 1-(p-tolylsulfonyl)-3-(2-endo-hydroxy-3-endo-D-bornyl)urea
Manufacturers' Codes: Ro-6-4563
Trademarks: Gluborid (Grenthal); Glutril (Roche)
Molecular Formula: C18H26N2O4S
Molecular Weight: 366.48
Percent Composition: C 58.99%, H 7.15%, N 7.64%, O 17.46%, S 8.75%
Literature References: Prepn: H. Bretschneider et al., Monatsh. Chem. 100, 2133 (1969). See also: eidem, ZA 6706161; eidem, US 3770761; eidem, ZA 6902395; eidem, US 3654357 (1968, 1973, 1969, 1972, all to Hoffmann-La Roche). Comprehensive review of pharmacology: Arzneim.-Forsch. 22, 2153-2222 (1972).
Properties: Crystals, mp 192-195° (ethanol-water); also reported as 195-198°. [a]D +63.8° (ethanol).
Melting point: mp 192-195° (ethanol-water); also reported as 195-198°
Optical Rotation: [a]D +63.8° (ethanol)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.
Gliclazide Gliotoxin Glipizide Gliquidone Glisoxepid

Glibornuride
Glibornuride.png
Identifiers
CAS number 26944-48-9 YesY
PubChem 33649
KEGG D02427 YesY
ATC code A10BB04
Jmol-3D images Image 1
Properties
Molecular formula C18H26N2O4S
Molar mass 366.48 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Glibornuride (INN) is an anti-diabetic drug from the group of sulfonylureas.[1]