Gliquidone

Title: Gliquidone
CAS Registry Number: 33342-05-1
CAS Name: N-[(Cyclohexylamino)carbonyl]-4-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolinyl)ethyl]benzenesulfonamide
Additional Names: 1-cyclohexyl-3-[[p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]phenyl]sulfonyl]urea; 1,2,3,4-tetrahydro-2-[p-(N¢-cyclohexylureido-N-sulfonyl)phenethyl]-4,4-dimethyl-7-methoxyisoquinoline-1,3-dione
Manufacturers' Codes: AR-DF 26
Trademarks: Glurenorm (Thomae)
Molecular Formula: C27H33N3O6S
Molecular Weight: 527.63
Percent Composition: C 61.46%, H 6.30%, N 7.96%, O 18.19%, S 6.08%
Literature References: Prepn: E. Kutter et al., DE 2000339 (1971 to Thomae); eidem, US 3708486 (1973 to Boehringer, Ing.); eidem, DE 2011126 (1971 to Thomae), C.A. 76, 14359e (1972). Pharmacokinetics and metabolism: Kopitar, Arzneim.-Forsch. 25, 1455 (1975); Kopitar et al., ibid. 1933.
Properties: Crystals from boiling methanol, mp 180-182°.
Melting point: mp 180-182°
Derivative Type: Sodium salt
Properties: Sinters at 160°. LD50 in mice: >2 g/kg orally; 234 mg/kg i.v. (Kutter, 1973).
Toxicity data: LD50 in mice: >2 g/kg orally; 234 mg/kg i.v. (Kutter, 1973)
Therap-Cat: Antidiabetic.
Keywords: Antidiabetic; Sulfonylurea Derivatives.
Glisoxepid Globin Glucagon Glucagon-Like Peptides Glucametacin

Gliquidone
Gliquidone.svg
Systematic (IUPAC) name
N-(cyclohexylcarbamoyl)-4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-3,4-dihydroisoquinolin-2(1H)-yl)ethyl]benzenesulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. C
Legal status POM (UK)
Routes Oral
Pharmacokinetic data
Excretion 95% Biliary, 5% Renal
Identifiers
CAS number 33342-05-1
ATC code A10BB08
PubChem CID 91610
DrugBank DB01251
ChemSpider 82719 YesY
UNII C7C2QDD75P YesY
KEGG D02430 YesY
ChEMBL CHEMBL383634 YesY
Chemical data
Formula C27H33N3O6S 
Mol. mass 527.634 g/mol
 YesY (what is this?)  (verify)

Gliquidone (INN, sold under the trade name Glurenorm) is an anti-diabetic drug in the sulfonylurea class. It is used in the treatment of diabetes mellitus type 2. It is marketed by the pharmaceutical company Boehriger Ingelheim, Germany.