Title: Globin
Literature References: The colorless, basic protein of hemoglobin. Formed from tissue protein in the body, the globin part of catabolized hemoglobin is re-used (unlike heme, the prosthetic group of hemoglobin). Prepn from ox hemoglobin: Anson, Mirsky, J. Gen. Physiol. 13, 469 (1930). Globin from normal adult human hemoglobin consists of four polypeptide chains: two a-chains and two b-chains. The a-chain contains 141, the b-chain 146 amino acids. Thus globin contains 574 amino acids and has an approx mol wt of 62,000. Abnormal globins may contain g- and d-chains. Structure: Braunitzer et al., Z. Physiol. Chem. 325, 283 (1961); 331, 1 (1963); Konigsberg et al., J. Biol. Chem. 237, 1549, 2547 (1962); 238, 2016, 2028 (1963). Review of prepn and properties: Rossi Fanelli et al., Adv. Protein Chem. 19, 124 (1964). Review: Braunitzer et al., ibid. 1.
Properties: Denatures rapidly above 17°. At pH values near neutrality, combines with ferroprotoporphyrin to yield hemoglobin, or with ferriprotoporphyrin to yield methemoglobin.
Glucagon Glucagon-Like Peptides Glucametacin Glucamine Glucofrangulin

Globin family
PDB 1hba EBI.jpg
Structure of deoxyhemoglobin Rothschild 37 beta Trp----Arg: a mutation that creates an intersubunit chloride-binding site.[1]
Symbol Globin
Pfam PF00042
Pfam clan CL0090
InterPro IPR000971
SCOP 1hba
CDD cd01067
PDB 1s56 EBI.jpg
crystal structure of "truncated" hemoglobin n (hbn) from mycobacterium tuberculosis, soaked with xe atoms
Symbol Bac_globin
Pfam PF01152
Pfam clan CL0090
InterPro IPR001486
SCOP 1dlw

The globins are a family of globular proteins, which are thought to share a common ancestor. These proteins all incorporate the globin fold, a series of eight alpha helical segments. Two prominent members of this family include myoglobin and hemoglobin, which both bind the heme (also haem) prosthetic group. Both of these proteins are reversible oxygen binders.

Globins are haem-containing proteins involved in binding and/or transporting oxygen. They belong to a very large and well studied family that is widely distributed in many organisms.[2]