Granulocyte Colony-Stimulating Factor

Title: Granulocyte Colony-Stimulating Factor
CAS Registry Number: 143011-72-7
Additional Names: CSF-b; G-CSF; GM-DF; MGI-2; pluripoietin
Literature References: Hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. Glycoprotein of mol wt 18-22 kDa; produced in response to specific stimulation by a variety of cells including monocytes, fibroblasts and endothelial cells. Murine and human molecules exhibit cross species reactivity. Originally identified as a differentiation factor for murine leukemic cells. Characterization in mouse serum: J. Lotem et al., Int. J. Cancer 25, 763 (1980); A. W. Burgess, D. Metcalf, ibid. 26, 647 (1980). Purification of murine G-CSF: N. A. Nicola et al., J. Biol. Chem. 258, 9017 (1983); of human G-CSF: K. Welte et al., Proc. Natl. Acad. Sci. USA 82, 1526 (1985); N. Nicola et al., Nature 314, 625 (1985); H. Nomura et al., EMBO J. 5, 871 (1986). Production of human G-CSF by recombinant DNA technology: L. M. Souza et al., Science 232, 61 (1986); S. Nagata et al., Nature 319, 415 (1986). Review of clinical potential and comparison with GM-CSF: W. P. Steward, Lancet 342, 153-157 (1993). Reviews: G. D. Demetri, J. D. Griffin, Blood 78, 2791-2808 (1991); L. S. Tkatch, D. J. Tweardy, Lymphokine Cytokine Res. 12, 477-488 (1993). Review of role in infectious diseases: D. C. Dale et al., J. Infect. Dis. 172, 1061-1075 (1995).
Derivative Type: Filgrastim
CAS Registry Number: 121181-53-1
CAS Name: N-L-Methionylcolony-stimulating factor (human clone 1034)
Additional Names: recombinant methionyl human G-CSF; r-metHuG-CSF
Manufacturers' Codes: KRN-8601
Trademarks: Neupogen (Amgen)
Literature References: 175 amino acid peptide produced in E. coli by recombinant DNA technology; mol wt 18.8 kDa. Differs from endogenous human G-CSF by the addition of an N-terminal methionine and the absence of glycosylation. Prepn: L. M. Souza, EP 237545 (1987 to Kirin-Amgen); idem, US 5580755 (1996 to Amgen). Clinical trial in severe chronic neutropenia: D. C. Dale et al., Blood 81, 2496 (1993). Book: Filgrastim in Clinical Practice, G. Morstyn, T. M. Dexter, Eds. (Marcel Dekker, New York, 1994) 351 pp.
Derivative Type: Pegfilgrastim
CAS Registry Number: 208265-92-3
CAS Name: 3-Hydroxypropyl-N-methionylcolony-stimulating factor (human) 1-ether with a-methyl-w-hydroxypoly(oxy-1,2-ethanediyl)
Trademarks: Neulasta (Amgen)
Literature References: Pegylated form of filgrastim; modified by the addition of a 20 kDa linear molecule of polyethylene glycol. Pharmacology: G. Molineux et al., Exp. Hematol. 27, 1724 (1999). Series of articles on chemistry, pharmacokinetics and clinical efficacy: Pharmacotherapy 23, 1S-19S (2003). Review of prepn and development: G. Molineux, Curr. Pharm. Des. 10, 1235-1244 (2004); of clinical experience in chemotherapy-induced neutropenia: A.-R. Waladkhani, Eur. J. Cancer Care 13, 371-379 (2004).
Derivative Type: Lenograstim
CAS Registry Number: 135968-09-1
Trademarks: Granocyte (Chugai); Neutrogin (Chugai)
Literature References: Glycoprotein with 174 amino acids and 4% sugar chains produced in Chinese hamster ovary cells by recombinant DNA technology; mol wt ~20 kDa. Closely resembles endogenous human G-CSF. Prepn: M. Ono et al., WO 8604605; eidem, EP 215126 (1986, 1987 both to Chugai). Clinical trial in bone-marrow transplantation: C. Gisselbrecht et al., Lancet 343, 696 (1994). Review of pharmacology and clinical experience: C. J. Dunn, K. L. Goa, Drugs 59, 681-717 (2000).
Derivative Type: Nartograstim
CAS Registry Number: 134088-74-7
CAS Name: 1-(N-L-Methionyl-L-alanine)-3-L-threonine-4-L-tyrosine-5-L-arginine-17-L-serinecolony-stimulating factor (human clone 1034)
Additional Names: marograstim
Manufacturers' Codes: KW-2228
Trademarks: Neu-up (Kyowa)
Literature References: G-CSF mutein of 175 amino acids produced in E. coli by recombinant DNA technology; mol wt 18.9 kDa. Prepn: Y. Yokoo et al., JP 2234692 (1990 to Kyowa), C.A. 114, 183900 (1991). In vitro activity: T. Suzuki et al., Acta Haematol. 87, 181 (1992). ELISA determn in plasma: T. Kuwabara et al., J. Pharmacobio-Dyn. 25, 121 (1992).
Therap-Cat: Hematopoietic; antineutropenic.
Keywords: Antineutropenic; Hematopoietic.
Granulocyte-Macrophage Colony-Stimulating Factor Graphite Fluoride Graphitic Acid Gratiogenin Gratioside

Colony stimulating factor 3 (granulocyte)

Ribbon diagram showing three molecules of human G-CSF. From PDB 1rhg
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols CSF3 (; C17orf33; CSF3OS; GCSF)
External IDs OMIM: 138970 MGI: 1339751 HomoloGene: 7677 GeneCards: CSF3 Gene
RNA expression pattern
PBB GE CSF3 207442 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 1440 12985
Ensembl ENSG00000108342 ENSMUSG00000038067
UniProt P09919 P09920
RefSeq (mRNA) NM_000759 NM_009971
RefSeq (protein) NP_000750 NP_034101
Location (UCSC) Chr 17:
38.17 – 38.17 Mb
Chr 11:
98.7 – 98.7 Mb
PubMed search [1] [2]

Granulocyte colony-stimulating factor (G-CSF or GCSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein that stimulates the bone marrow to produce granulocytes and stem cells and release them into the bloodstream. Functionally, it is a cytokine and hormone, a type of colony-stimulating factor, and is produced by a number of different tissues.

G-CSF also stimulates the survival, proliferation, differentiation, and function of neutrophil precursors and mature neutrophils. G-CSF regulates them using Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Ras/mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) signal transduction pathway.