Guanabenz

Title: Guanabenz
CAS Registry Number: 5051-62-7
CAS Name: 2-[(2,6-Dichlorophenyl)methylene]hydrazinecarboximidamide
Additional Names: [(2,6-dichlorobenzylidene)amino]guanidine; N-(2,6-dichlorobenzylidene)-N¢-amidinohydrazine
Manufacturers' Codes: NSC-68982
Molecular Formula: C8H8Cl2N4
Molecular Weight: 231.08
Percent Composition: C 41.58%, H 3.49%, Cl 30.68%, N 24.25%
Literature References: a2-Adrenergic agonist. Prepn: J. Yates, E. Haddock, GB 1019120 (1966 to Shell), C.A. 64, 11132h (1966). Use as antihypertensive: W. J. Houlihan et al., DE 1804634 (1969 to Sandoz), C.A. 71, 89976j (1969). Pharmacology: T. Baum et al., J. Pharmacol. Exp. Ther. 171, 276 (1970); E. Lampa et al., Experientia 36, 228 (1980). Disposition of 14C-guanabenz in humans: R. H. Meacham et al., Clin. Pharmacol. Ther. 27, 44 (1980). Mechanism of action: G. F. DiBona, J. Cardiovasc. Pharmacol. 6, Suppl. 3, S543 (1984). Radioimmunoassay determn in plasma: H. Tatsumi, Arzneim.-Forsch. 34, 1704 (1984). Clinical studies: A. Reppelli et al., Boll. Soc. Ital. Cardiol. 23, 177 (1978); C. V. Ram et al., J. Clin. Pharmacol. 19, 148 (1979). Clinical studies in opiate withdrawal: F. S. Tennant, R. A. Rawson, NIDA Res. Monogr. Ser. 49, 338 (1984); J. T. Murphy, Drug Intell. Clin. Pharm. 19, 32 (1985). Review of pharmacodynamic properties and therapeutic efficacy: B. Holmes et al., Drugs 26, 212-229 (1983). Comprehensive description: C. M. Shearer, Anal. Profiles Drug Subs. 15, 319-336 (1986).
Properties: White solid from acetonitrile, mp 227-229° (dec).
Melting point: mp 227-229° (dec)
Derivative Type: Monoacetate
CAS Registry Number: 23256-50-0
Manufacturers' Codes: Wy-8678
Trademarks: Rexitene (LPD); Tenelid (Helsinn); Wytensin (Wyeth)
Molecular Formula: C10H12Cl2N4O2
Molecular Weight: 291.13
Percent Composition: C 41.26%, H 4.15%, Cl 24.36%, N 19.24%, O 10.99%
Properties: Solid, mp 192.5° (dec). Soly at 25° (mg/ml): water 11; alcohol 50; propylene glycol 100; chloroform 0.6; ethyl acetate 1.
Melting point: mp 192.5° (dec)
Therap-Cat: Antihypertensive.
Keywords: a-Adrenergic Agonist; Antihypertensive; Guanidine Derivatives.
Guanacline Guanadrel Guanazodine Guanfacine Guanidine

Guanabenz
Guanabenz.svg
Guanabenz sf.png
Systematic (IUPAC) name
2-(2,6-dichlorobenzylidene)hydrazinecarboximidamide
Clinical data
AHFS/Drugs.com Consumer Drug Information
MedlinePlus a686003
Pregnancy cat. C (US)
Legal status  ?
Pharmacokinetic data
Protein binding 90%
Half-life 6 hours
Identifiers
CAS number 5051-62-7
ATC code None
PubChem CID 5702063
DrugBank DB00629
ChemSpider 4642445 YesY
UNII GGD30112WC YesY
KEGG D04375 YesY
ChEMBL CHEMBL420 YesY
Chemical data
Formula C8H8Cl2N4 
Mol. mass 231.081 g/mol
 YesY (what is this?)  (verify)

Guanabenz (pronounced GWAHN-a-benz, sold under the trade name Wytensin) is an alpha agonist of the alpha-2 type that is used as an antihypertensive drug. It is used to treat high blood pressure (hypertension).[1][2]

The most common side effects during guanabenz therapy are dizziness, drowsiness, dry mouth, headache and weakness.

Guanabenz can make one drowsy or less alert, therefore driving or operating dangerous machinery is not recommended.