Hydroxydione Sodium

Title: Hydroxydione Sodium
CAS Registry Number: 53-10-1
CAS Name: 21-(3-Carboxy-1-oxopropoxy)-5b-pregnane-3,20-dione sodium salt
Additional Names: 21-hydroxypregnane-3,20-dione sodium hemisuccinate; hydroxydione succinate
Trademarks: Presuren; Viadril
Molecular Formula: C25H35NaO6
Molecular Weight: 454.53
Percent Composition: C 66.06%, H 7.76%, Na 5.06%, O 21.12%
Literature References: Prepd by palladium reduction of deoxycorticosterone followed by treatment with succinic anhydride and formation of the sodium salt: Laubach, US 2708651 (1955 to Pfizer); Laubach et al., Science 122, 78 (1955).
Properties: Lyophilized, fluffy white powder. Dec 193-203°. uv max: 280 nm (e 93.2). Sol in water, in mildly alkaline buffer solns, acetone, chloroform. pH of 2% aq soln 8.5-9.8.
Absorption maximum: uv max: 280 nm (e 93.2)
Derivative Type: Free acid
Properties: mp 195-197°. [a]D20 +95° in chloroform.
Melting point: mp 195-197°
Optical Rotation: [a]D20 +95° in chloroform
Therap-Cat: Anesthetic (intravenous).
Keywords: Anesthetic (Intravenous).
Hydroxyglutamic Acid Hydroxylamine Hydroxylupanine Hydroxymercurichlorophenols Hydroxypethidine