Hydroxyphenamate

Title: Hydroxyphenamate
CAS Registry Number: 50-19-1
CAS Name: 2-Phenyl-1,2-butanediol 1-carbamate
Additional Names: carbamic acid b-ethyl-b-hydroxyphenethyl ester; b-ethyl-b-hydroxyphenethyl carbamic acid ester; b-ethyl-b-hydroxyphenethyl carbamate; 2-hydroxy-2-phenylbutyl carbamate
Manufacturers' Codes: AL-0361
Trademarks: Listica
Molecular Formula: C11H15NO3
Molecular Weight: 209.24
Percent Composition: C 63.14%, H 7.23%, N 6.69%, O 22.94%
Literature References: Prepd from b-ethyl-b-hydroxyphenethyl alcohol and ethyl chloroformate followed by reaction with ammonia: Sifferd, Braitberg, US 3066164 (1962 to Armour-Pharm.). Pharmacology and toxicology: Bastian, Clements, Dis. Nerv. Syst. 22, 9 (1961).
Properties: Crystals, mp 55-56.5°. Soly in water at 25°: 2.5% w/v. LD50 orally in mice: 830 mg/kg (Bastian, Clements).
Melting point: mp 55-56.5°
Toxicity data: LD50 orally in mice: 830 mg/kg (Bastian, Clements)
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Carbamates.
Status: This monograph has been retired and is no longer subject to revision or update.
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