Hymecromone

Title: Hymecromone
CAS Registry Number: 90-33-5
CAS Name: 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one
Additional Names: 7-hydroxy-4-methylcoumarin; 7-hydroxy-4-methyl-2-oxo-3-chromene; 4-methylumbelliferone; b-methylumbelliferone; imecromone; 4-MU
Trademarks: Bilcolic (Unifa); Biliton H (Berlin-Chemie); Cantabilin (Formenti); Cantabiline; Cholonerton (Dolorgiet); Cholspasmin (Lipha); Cumarote C (Towa Yakuhin); Himecol (Kissei); Medilla (Omega); Mendiaxon (Roland)
Molecular Formula: C10H8O3
Molecular Weight: 176.17
Percent Composition: C 68.18%, H 4.58%, O 27.25%
Literature References: Prepd from resorcinol and ethyl acetoacetate: Pechmann, Duisberg, Ber. 16, 2119 (1883); Russell, Frye, Org. Synth. 21, 23 (1941); Woods, Sapp, J. Org. Chem. 27, 3703 (1962). Use in determn of nitric acid: F. J. Welcher, Organic Analytical Reagents vol. 1 (Van Nostrand, New York, 1947) pp 214-215.
Properties: Crystals from alc, mp 194-195° (Woods, Sapp), formerly reported as 185-186° (Pechmann, Duisberg). uv max (methanol): 221, 251, 322.5 nm. Blue fluorescence in alcohol + water. Sol in methanol, glacial acetic acid; slightly sol in ether, chloroform. Practically insol in cold water.
Melting point: mp 194-195° (Woods, Sapp)
Absorption maximum: uv max (methanol): 221, 251, 322.5 nm
Use: Analytical reagent.
Therap-Cat: Choleretic; antispasmodic.
Keywords: Antispasmodic; Choleretic.
Hymecromone O,O-Diethyl Phosphorothioate Hymexazol Hyodeoxycholic Acid Hyoscyamine Hyoscyamus

Hymecromone
Hymecromone.png
Systematic (IUPAC) name
7-Hydroxy-4-methylchromen-2-one
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Identifiers
CAS number 90-33-5 YesY
ATC code A05AX02
PubChem CID 5280567
DrugBank DB07118
ChemSpider 4444190 YesY
UNII 3T5NG4Q468 YesY
KEGG D00170 YesY
ChEBI CHEBI:17224 YesY
ChEMBL CHEMBL12208 YesY
Synonyms 4-Methylumbelliferone
Chemical data
Formula C10H8O3 
Mol. mass 176.17 g/mol
 YesY (what is this?)  (verify)

Hymecromone (4-methylumbelliferone) is a drug used in bile therapy. It is used as choleretic and antispasmodic drugs and as a standard for the fluorometric determination of enzyme activity.

Hymecromone is a crystalline solid with a melting point of 194–195 °C. It is soluble in methanol and glacial acetic acid.