Julocrotine

Title: Julocrotine
CAS Registry Number: 492-87-5
CAS Name: N-[2,6-Dioxo-1-(2-phenylethyl)-3-piperidinyl]-2-methylbutanamide
Additional Names: yulocrotine; b-phenylethylimide of N-a-methylbutyrylglutamic acid
Molecular Formula: C18H24N2O3
Molecular Weight: 316.39
Percent Composition: C 68.33%, H 7.65%, N 8.85%, O 15.17%
Literature References: Isoln from root of Julocroton montevideensis Klotzsch, Euphorbiaceae: Anastasi, An. Asoc. Quim. Argent. 23, 348 (1925), C.A. 20, 2332 (1926). Structure: Nakano et al., J. Org. Chem. 26, 1184 (1961).
Properties: Crystals from ether + petr ether, mp 108-109°. [a]D -9° (c = 1.24 in chloroform), -50.1° (c = 1.19 in methanol). uv max (ethanol): 252, 258, 264, 268 nm (log e 2.43, 2.44, 2.30, 2.18). Sol in alc, benzene, chloroform, ether, slightly in petr ether.
Melting point: mp 108-109°
Optical Rotation: [a]D -9° (c = 1.24 in chloroform), -50.1° (c = 1.19 in methanol)
Absorption maximum: uv max (ethanol): 252, 258, 264, 268 nm (log e 2.43, 2.44, 2.30, 2.18)
Status: This monograph has been retired and is no longer subject to revision or update.
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