Kallidin

Title: Kallidin
CAS Registry Number: 342-10-9
CAS Name: N2-L-Lysylbradykinin
Additional Names: kallidin-10; kallidin II
Molecular Formula: C56H85N17O12
Molecular Weight: 1188.38
Percent Composition: C 56.60%, H 7.21%, N 20.04%, O 16.16%
Literature References: A hypotensive and smooth muscle-stimulating principle formed by the proteolysis of kininogen by glandular and other kallikreins, q.v. The decapeptide structure is a homologue of bradykinin, q.v.: Werle et al., Z. Physiol. Chem. 326, 174 (1961). Synthesis: Nicolaides et al., Biochem. Biophys. Res. Commun. 6, 210 (1961); Pless et al., Helv. Chim. Acta 45, 394 (1962).
Properties: Amorphous precipitate. [a]D21 -57° (c = 1 in N acetic acid). Rf value in a butanol/acetic acid/water system (70:10:20) 0.15.
Optical Rotation: [a]D21 -57° (c = 1 in N acetic acid)
Therap-Cat: Vasodilator.
Keywords: Vasodilator (Peripheral).
Kallikrein Kamala Kanamycin Karanjin Karaya Gum

Kallidin
Kallidin 3D.png
Identifiers
CAS number 342-10-9
PubChem 5311111
ChemSpider 4470640 YesY
MeSH Kallidin
Jmol-3D images Image 1
Properties
Molecular formula C56H85N17O12
Molar mass 1188.38 g/mol
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Kallidin is a bioactive kinin formed in response to injury from kininogen precursors through the action of kallikreins.

Kallidin is a decapeptide that can be converted to bradykinin by the aminopeptidase enzyme.

It can be a substrate for carboxypeptidase M and N.[1]

Kallidin is identical to bradykinin with an additional lysine residue added at the N-terminal end and signals through the bradykinin receptor.