Ketazolam

Title: Ketazolam
CAS Registry Number: 27223-35-4
CAS Name: 11-Chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione
Manufacturers' Codes: U-28774
Trademarks: Anseren (Novartis); Unakalm (Pharmacia & Upjohn)
Molecular Formula: C20H17ClN2O3
Molecular Weight: 368.81
Percent Composition: C 65.13%, H 4.65%, Cl 9.61%, N 7.60%, O 13.01%
Literature References: Prepn: J. Szmuszkovicz, DE 1947226; idem, US 3573282 (1970, 1971 both to Upjohn). Synthesis and structure: J. Szmuszkovicz et al., Tetrahedron Lett. 1971, 3665. Analysis by HPLC: D. J. Weber, J. Pharm. Sci. 61, 1797 (1972). Pharmacology: V. H. Sethy, Arch. Exp. Pathol. Pharmakol. 301, 157 (1978). Clinical studies: L. F. Fabre, J. Int. Med. Res. 4, 50 (1976); L. A. Gottschalk, J. B. Cohn, Psychopharmacol. Bull. 14, 39 (1978).
Properties: Colorless prisms from chloroform/ether, mp 182-183.5° (sinters at 170°). uv max (ethanol): 202, 241 nm (e 40600; 18400).
Melting point: mp 182-183.5° (sinters at 170°)
Absorption maximum: uv max (ethanol): 202, 241 nm (e 40600; 18400)
NOTE: This is a controlled substance (depressant): 21 CFR, 1308.14.
Therap-Cat: Anxiolytic.
Keywords: Anxiolytic; Benzodiazepine Derivatives.
Kethoxal Ketipic Acid Ketorolac Khat Khellin

Ketazolam
Ketazolam.svg
Ketazolam3d.png
Systematic (IUPAC) name
11-chloro-8,12b-dihydro-2,8-dimethyl-12b-phenyl-4H-[1,3]oxazino[3,2-d][1,4]benzodiazepine-4,7(6H)-dione[1]
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat.  ?
Legal status Schedule IV(US)
Routes Oral
Pharmacokinetic data
Bioavailability  ?
Metabolism Hepatic
Half-life 26-200 hours
Excretion Renal
Identifiers
CAS number 27223-35-4 YesY
ATC code N05BA10
PubChem CID 33746
DrugBank DB01587
ChemSpider 31110 YesY
UNII 92A214MD7Y YesY
KEGG D04650 YesY
Chemical data
Formula C20H17ClN2O3 
Mol. mass 368.8
 YesY (what is this?)  (verify)

Ketazolam (marketed under the brand names Anseren, Ansieten, Ansietil, Marcen, Sedatival, Sedotime, Solatran and Unakalm) is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant properties.