Title: Muscimol
CAS Registry Number: 2763-96-4
CAS Name: 5-(Aminomethyl)-3(2H)-isoxazolone
Additional Names: 5-(aminomethyl)-3-isoxazolol; 5-aminomethyl-3-hydroxyisoxazole; 3-hydroxy-5-aminomethylisoxazole; agarin; pantherine
Molecular Formula: C4H6N2O2
Molecular Weight: 114.10
Percent Composition: C 42.11%, H 5.30%, N 24.55%, O 28.04%
Literature References: Potent CNS depressant and GABA agonist isolated from Amanita muscaria (L.) Fr., Agaricaceae. Structural identity with the insecticidal substances, pantherine and agarin: Onda et al., Chem. Pharm. Bull. 12, 751 (1964); Eugster et al., Tetrahedron Lett. 1965, 1813; Bowden, Drysdale, ibid. 727. Synthesis: Gagneux et al., ibid. 2077; Göth et al., Helv. Chim. Acta 50, 137 (1967); Bowden et al., J. Chem. Soc. C 1968, 172. Improved syntheses: Nakamura, Chem. Pharm. Bull. 19, 46 (1971); P. Krogsgaard-Larsen, S. B. Christensen, Acta Chem. Scand. B B30, 281 (1976); A. Barco et al., J. Chem. Res. Synop. 1979, 176; B. E. McCarry, M. Savard, Tetrahedron Lett. 22, 5153 (1981); V. Jager, M. Frey, Ann. 1982, 817. Conformational structure: L. Brehm et al., ibid. 26, 1298 (1972). Industrial patents: Hafliger, Gagneux, US 3242190, US 3397209 (1966, 1968 both to Geigy). Pharmacology: Theobald et al., Arzneim.-Forsch. 18, 311 (1968). Review of pharmacology: F. V. DeFeudis, Neurochem. Res. 5, 1047-1068 (1980).
Properties: Crystals, mp 175° (dec). LD50 in mice (mg/kg): 3.8 s.c., 2.5 i.p.; in rats (mg/kg): 4.5 i.v., 45 orally (Theobald).
Melting point: mp 175° (dec)
Toxicity data: LD50 in mice (mg/kg): 3.8 s.c., 2.5 i.p.; in rats (mg/kg): 4.5 i.v., 45 orally (Theobald)
Use: As a molecular probe to study GABA receptors.
Muscone Musks Mustard Muzolimine Mycaminose

Muscimol chemical structure.svg
CAS number 2763-96-4 N
PubChem 4266
ChemSpider 4116 YesY
Jmol-3D images Image 1
Molecular formula C4H6N2O2
Molar mass 114.10 g mol−1
Melting point 184 to 185 °C; 363 to 365 °F; 457 to 458 K
Solubility in water very soluble
Solubility in ethanol slightly soluble
Solubility in methanol very soluble
 N (verify) (what is: YesY/N?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Muscimol (agarin, pantherine) is the major psychoactive alkaloid present in many mushrooms of the Amanita genus. Muscimol is a potent, selective agonist for the GABAA receptors and displays sedative-hypnotic effects.