Title: Muzolimine
CAS Registry Number: 55294-15-0
CAS Name: 5-Amino-2-[1-(3,4-dichlorophenyl)ethyl]-2,4-dihydro-3H-pyrazol-3-one
Additional Names: 3-amino-1-(3,4-dichloro-a-methylbenzyl)-2-pyrazolin-5-one
Manufacturers' Codes: Bay g 2821
Trademarks: Edrul (Bayer)
Molecular Formula: C11H11Cl2N3O
Molecular Weight: 272.13
Percent Composition: C 48.55%, H 4.07%, Cl 26.06%, N 15.44%, O 5.88%
Literature References: High-ceiling loop diuretic. Prepn: E. Möller et al., DE 2319278; eidem, US 3957814 (1974, 1976 both to Bayer); eidem, Experientia 33, 382 (1977). In vitro effects: H. J. Kramer, Pharmatherapeutica 1, 353 (1977). Mechanism of action: M. Mussche, N. Lameire, Curr. Med. Res. Opin. 4, 462 (1977). Pharmacology: K. Meng et al., ibid. 555. Pharmacokinetics: O. Broers et al., Eur. J. Clin. Pharmacol. 15, 105 (1979); eidem, Curr. Med. Res. Opin. 6, 431 (1980). Use in advanced renal disease: A. D. Canton et al., Br. Med. J. 282, 595 (1981); P. Schmidt et al., Eur. J. Clin. Pharmacol. 20, 23 (1981). Toxicological studies: D. Lorke, P. Mürmann, Curr. Med. Res. Opin. 4, 716 (1977). Symposium on pharmacology, pharmacodynamics, toxicology, clinical studies: Clin. Nephrol. 19, Suppl. 1, S1-S117 (1983).
Properties: Cryst from methanol, mp 127-129°. LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann).
Melting point: mp 127-129°
Toxicity data: LD50 in mice, rats, dogs, rabbits (mg/kg): 1794, 1559, 2000, 1250 orally (Lorke, Mürmann)
Therap-Cat: Diuretic; antihypertensive.
Keywords: Antihypertensive; Diuretic.
Status: This monograph has been retired and is no longer subject to revision or update.
Mycaminose Mycarose Mycelianamide Mycetins Myclobutanil

Systematic (IUPAC) name
Clinical data
Legal status Withdrawn
ATC code C03CD01
PubChem CID 41386
UNII 07Z36289ZX YesY
KEGG D05093 YesY
Chemical data
Formula C11H11Cl2N3O 
Mol. mass 272.13 g/mol
 YesY (what is this?)  (verify)

Muzolimine is a loop diuretic.[1] It is a pyrazole diuretic which was used for treatment of hypertension but was withdrawn worldwide because of severe neurological side effects.[2]