Title: Oxantel
CAS Registry Number: 36531-26-7
CAS Name: (E)-3-[2-(1,4,5,6-Tetrahydro-1-methyl-2-pyrimidinyl)ethenyl]phenol
Additional Names: (E)-m-[2-(1,4,5,6-tetrahydro-1-methyl-2-pyrimidinyl)vinyl]phenol; 1-methyl-1,4,5,6-tetrahydro-2-[2-(3-hydroxyphenyl)vinyl]pyrimidine
Manufacturers' Codes: CP-14445
Molecular Formula: C13H16N2O
Molecular Weight: 216.28
Percent Composition: C 72.19%, H 7.46%, N 12.95%, O 7.40%
Literature References: Analog of pyrantel, q.v., with activity vs whipworms (Trichuris spp.). Prepn: J. W. Mc Farland, ZA 6804589 corresp to US 3579510 and US 3708584 (1968, 1971, 1973 all to Pfizer). Synthesis and evaluation in whipworm control: J. W. Mc Farland, H. L. Howes J. Med. Chem. 15, 365 (1972). Evaluation vs Trichuris in dogs: H. L. Howes, Proc. Soc. Exp. Biol. Med. 139, 394 (1972). Efficacy vs T. trichiuris in humans: E. L. Lee et al., Am. J. Trop. Med. Hyg. 25, 563 (1976); vs T. suis in swine: M. Robinson, Vet. Parasitol. 5, 223 (1979). Anthelmintic effects of combination with pyrantel pamoate: B. Sinniah, D. Sinniah, Ann. Trop. Med. Parasitol. 75, 315 (1981).
Derivative Type: Hydrochloride
Molecular Formula: C13H16N2O.HCl
Molecular Weight: 252.74
Percent Composition: C 61.78%, H 6.78%, N 11.08%, O 6.33%, Cl 14.03%
Properties: Crystals from ethanol, mp 207-208°. uv max (water): 231, 274 nm (e 12700, 20100).
Melting point: mp 207-208°
Absorption maximum: uv max (water): 231, 274 nm (e 12700, 20100)
Derivative Type: Pamoate
CAS Registry Number: 68813-55-8
Additional Names: Oxantel embonate
Manufacturers' Codes: CP-14445-16
Trademarks: Telopar (Pfizer)
Molecular Formula: C13H16N2O.C23H16O6
Molecular Weight: 604.65
Percent Composition: C 71.51%, H 5.33%, N 4.63%, O 18.52%
Derivative Type: Mixture with pyrantel pamoate (1:1) see Pyrantel
Therap-Cat: Anthelmintic (Nematodes).
Therap-Cat-Vet: Anthelmintic (Nematodes).
Keywords: Anthelmintic (Nematodes).
Oxapropanium Iodide Oxaprozin Oxatomide Oxazepam Oxazidione

Systematic (IUPAC) name
Clinical data
Legal status  ?
CAS number 68813-55-8 YesY
ATC code P02CC02 QP52AF03
PubChem CID 5281087
KEGG D00806 YesY
Chemical data
Formula C13H16N2O 
Mol. mass 216.28 g/mol
 YesY (what is this?)  (verify)

Oxantel is an anthelmintic. It has typically been used human and animal use as a standard treatment for intestinal worms.

Oxantel is currently[when?] being experimented with for the treatment of periodontal disease by the Cooperative Research Centre for Oral Health Science (CRC). Professor Eric Reynolds (also the head of Dental School at the University of Melbourne, Australia) and his Associate Professor Stuart Dashper are currently testing its ability as a Fumarate reductase inhibitor.

Fumarate reductase is an enzyme that has been found in the pathogenic bacteria in the biofilm in periodontal pockets. This bacteria has the ability to convert blood components into energy and for the bacteria to be virulent. Such bacteria would starve without this enzyme. As such, the role of the Oxantel as a fumarate reductase inhibitor would be to kill the bacteria responsible for periodontal disease.