Oxidronic Acid

Title: Oxidronic Acid
CAS Registry Number: 15468-10-7
CAS Name: (Hydroxymethylene)bisphosphonic acid
Additional Names: (hydroxymethylene)diphosphonic acid; HDP; HMDP
Molecular Formula: CH6O7P2
Molecular Weight: 192.00
Percent Composition: C 6.26%, H 3.15%, O 58.33%, P 32.26%
Literature References: Bisphosphonate similar to etidronic acid, q.v. Prepn: O. T. Quimby, FR 1506840; idem, US 3422137 (1967, 1969 both to Procter & Gamble); of sodium salt: idem et al., J. Org. Chem. 32, 4111 (1967). Prepn of 99mTc-complex: J. A. Bevan, EP 7676; idem, US 4247534 (1980, 1981 both to Procter & Gamble); and osteotropic properties: T. S. T. Wang et al., J. Nucl. Med. 21, 767 (1980). Biodistribution: J. A. Bevan et al., ibid. 961. Radiochemical purity: W. Majewski et al., J. Nucl. Med. Technol. 11, 23 (1983). Clinical evaluation as skeletal imaging agent: P. A. Domstad et al., Radiology 136, 209 (1980). Diagnostic use in Paget's disease: A. Evans et al., Eur. J. Nucl. Med. 18, 757 (1991); for localization of bone metastases: F. Tenenbaum et al., ibid. 20, 1168 (1993).
Derivative Type: Sodium salt
CAS Registry Number: 14255-61-9
Additional Names: Disodium monohydroxy methylene diphosphonate; oxidronate sodium
Molecular Formula: CH4Na2O7P2
Molecular Weight: 235.97
Percent Composition: C 5.09%, H 1.71%, Na 19.49%, O 47.46%, P 26.25%
Properties: Crystals from methanol/water (6/1), mp 297-300°.
Melting point: mp 297-300°
Derivative Type: 99mTc-complex
CAS Registry Number: 72945-61-0
Additional Names: Technetium 99mTc oxidronate
Trademarks: TechneScan HDP (Mallinckrodt); Osteoscan-HDP (Mallinckrodt)
Therap-Cat: 99mTc-complex as diagnostic aid (radioactive imaging agent).
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