Oxprenolol

Title: Oxprenolol
CAS Registry Number: 6452-71-7
CAS Name: 1-[(1-Methylethyl)amino]-3-[2-(2-propenyloxy)phenoxy]-2-propanol
Additional Names: 1-[o-(allyloxy)phenoxy]-3-(isopropylamino)-2-propanol; 1-(isopropylamino)-2-hydroxy-3-[o-(allyloxy)phenoxy]propane
Molecular Formula: C15H23NO3
Molecular Weight: 265.35
Percent Composition: C 67.90%, H 8.74%, N 5.28%, O 18.09%
Literature References: b-Adrenergic blocker. Prepn: BE 669402 (1966 to Ciba), C.A. 65, 5402d (1966), corresp to GB 1077603. Metabolic studies: Garteiz, J. Pharmacol. Exp. Ther. 179, 354 (1971). Crystal structure of hydrochloride: J. M. Leger et al., Acta Crystallogr. 33B, 2156 (1977). Long-term prevention study in coronary heart disease: S. H. Taylor et al., N. Engl. J. Med. 307, 1293 (1982).
Properties: Crystals from hexane, mp 78-80°.
Melting point: mp 78-80°
Derivative Type: Hydrochloride
CAS Registry Number: 6452-73-9
Manufacturers' Codes: Ba-39089
Trademarks: Coretal (Polfa); Laracor (Lagap); Paritane (Berk); Trasicor (Novartis); Trasacor (Novartis)
Molecular Formula: C15H23NO3.HCl
Molecular Weight: 301.81
Percent Composition: C 59.69%, H 8.02%, N 4.64%, O 15.90%, Cl 11.75%
Properties: Crystals, mp 107-109°.
Melting point: mp 107-109°
Therap-Cat: Antihypertensive, antianginal, antiarrhythmic.
Keywords: ?Adrenergic Blocker; Antianginal; Antiarrhythmic; Antihypertensive; Aryloxypropanolamine Derivatives.
Oxyacanthine Oxybutynin Oxychlorosene Oxycinchophen Oxyclozanide

Oxprenolol
Oxprenolol.svg
Systematic (IUPAC) name
(RS)-1-[2-(Allyloxy)phenoxy]-3-(isopropylamino)propan-2-ol
Clinical data
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. C (AU)
Legal status Prescription only
Routes oral
Pharmacokinetic data
Bioavailability 20-70%
Metabolism Hepatic
Half-life 1-2hours
Excretion Renal
Lactic (In lactiferous females)
Identifiers
CAS number 6452-71-7 YesY
ATC code C07AA02
PubChem CID 4631
DrugBank DB01580
ChemSpider 4470 YesY
UNII 519MXN9YZR YesY
KEGG D08318 YesY
ChEMBL CHEMBL546 YesY
Chemical data
Formula C15H23NO3 
Mol. mass 265.348
 N (what is this?)  (verify)

Oxprenolol (Trasacor, Trasicor, Coretal, Laracor, Slow-Pren, Captol, Corbeton, Slow-Trasicor, Tevacor, Trasitensin, Trasidex) is a non-selective beta blocker with some intrinsic sympathomimetic activity. It is used for the treatment of angina pectoris, abnormal heart rhythms and high blood pressure.

Oxprenolol is a lipophilic beta blocker which passes the blood–brain barrier more easily than water soluble beta blockers. As such, it is associated with a higher incidence of CNS-related side effects than hydrophilic ligands such as atenolol, sotalol and nadolol.[1]

Oxprenolol is a potent beta blocker and should not be administered to asthmatics under any circumstances due to their low beta levels as a result of depletion due to other asthma medication, and because it can cause irreversible, often fatal, airway failure and inflammation.[2]