Pyronaridine

Title: Pyronaridine
CAS Registry Number: 74847-35-1
CAS Name: 4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
Additional Names: malaridine
Molecular Formula: C29H32ClN5O2
Molecular Weight: 518.05
Percent Composition: C 67.23%, H 6.23%, Cl 6.84%, N 13.52%, O 6.18%
Literature References: Prepn: X.-Y. Zheng et al., Yao Hsueh Hsueh Pao 14, 736 (1979), C.A. 93, 132397 (1980). HPLC determn in blood and urine: S. A. Wages et al., J. Chromatogr. 527, 115 (1990). In vitro activity vs drug resistant malaria: E. I. Elueze et al., J. Antimicrob. Chemother. 37, 511 (1996). Clinical trial: P. Ringwald et al., Lancet 347, 24 (1996). Reviews: B. Shao, Chin. Med. J. 103, 428-434 (1990); C. Chang et al., Trans. R. Soc. Trop. Med. Hyg. 86, 7-10 (1992).
Derivative Type: Tetraphosphate
CAS Registry Number: 76748-86-2
Molecular Formula: C29H32ClN5O2.4H3PO4
Molecular Weight: 910.03
Percent Composition: C 38.27%, H 4.87%, Cl 3.90%, N 7.70%, O 31.65%, P 13.61%
Properties: Hygroscopic, yellow needles, mp 233-236° (dec). Odorless; slightly bitter taste. Sol in water; very sparingly sol in ethanol. Insol in choroform, ether, and other organic solvents. LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao).
Melting point: mp 233-236° (dec)
Toxicity data: LD50 in mice (mg/kg): 251 ±33 i.m.; 1368 ±239 orally (Shao)
Therap-Cat: Antimalarial.
Keywords: Antimalarial.
Pyronine B Pyronine Y Pyrophosphoric Acid Pyrosulfuric Acid Pyrosulfuryl Chloride

Pyronaridine
Pyronaridine.svg
Systematic (IUPAC) name
4-[(7-chloro-2-methoxy-pyrido[3,2-b]quinolin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
Clinical data
Legal status CLP (EU): Acute Tox. 3(H301), Eye Dam. 1 (H318), Repr. 2 (H361), Aquatic Chronic 4 (H413)
Routes Oral, intramuscular injection, intravenous therapy
Identifiers
CAS number 74847-35-1 N
ATC code None
PubChem CID 5485198
ChemSpider 10647812 YesY
UNII TD3P7Q3SG6 YesY
ChEMBL CHEMBL35228 YesY
Chemical data
Formula C29H32ClN5O2 
Mol. mass 518.05 g/mol
 N (what is this?)  (verify)

Pyronaridine is an antimalarial drug. It was first synthesized in 1970 and has been in clinical use in China since the 1980s. It was first assayed by Adegoke and Babalola in 2006.[1]

It is one of the components of Pyramax.