Sulisatin

Title: Sulisatin
CAS Registry Number: 54935-03-4
CAS Name: 1,3-Dihydro-7-methyl-3,3-bis[4-(sulfooxy)phenyl]-2H-indol-2-one
Additional Names: 3,3-bis(p-hydroxyphenyl)-7-methyl-2-indolinone bis(hydrogen sulfate) (ester)
Molecular Formula: C21H17NO9S2
Molecular Weight: 491.49
Percent Composition: C 51.32%, H 3.49%, N 2.85%, O 29.30%, S 13.05%
Literature References: Deriv of isatin, which stimulates motility of the large intestine. Prepn: A. Hosta Pujol, S. Brosa Rabassa, DE 2521966 corresp to US 4053483 (1975, 1977 both to Andreu); F. Garrido et al., Eur. J. Med. Chem. 10, 143 (1975). Mechanism of action: J. Queralt et al., Arch. Farmacol. Toxicol. 1, 137 (1975). Laxative properties: M. Moreto et al., Eur. J. Pharmacol. 36, 221 (1976). Metabolism: eidem, Arzneim.-Forsch. 29, 1561 (1979).
Derivative Type: Disodium salt
CAS Registry Number: 54935-04-5
Manufacturers' Codes: DAN-603
Trademarks: Laxitex (Andreu)
Molecular Formula: C21H15NNa2O9S2
Molecular Weight: 535.45
Percent Composition: C 47.11%, H 2.82%, N 2.62%, Na 8.59%, O 26.89%, S 11.98%
Properties: White crystals, mp >360°. Slightly hygroscopic.
Melting point: mp >360°
Therap-Cat: Laxative.
Keywords: Laxative/Cathartic.
Status: This monograph has been retired and is no longer subject to revision or update.
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