Sulodexide

Title: Sulodexide
CAS Registry Number: 57821-29-1
Additional Names: Glucuronylglucosamineglicane sulfate
Manufacturers' Codes: KRX-101
Trademarks: Provenal (Pulitzer); Ravenol (Caber); Vessel (Alfa)
Literature References: Orally active heparinoid prepared from porcine intestinal mucosa. Mixture of 80% electrophoretically fast moving heparin and 20% dermatan sulfate; average mol wt <8000. Preparative method: P. Bianchini, DE 2426586; idem, US 3936351 (1975, 1976 both to Opocrin). Review of pharmacology: F. A. Ofosu, Semin. Thromb. Hemostasis 24, 127-138 (1998); J. Harenberg, Med. Res. Rev. 18, 1-20 (1998). Effect on albuminuria in diabetic patients: J. Skrha et al., Diabetes Res. Clin. Pract. 38, 25 (1997). Clinical trial in venous leg ulcers: S. Coccheri et al., Thromb. Haemostasis 87, 947 (2002); in deep venous thrombosis: B. M. Errichi et al., Angiology 55, 243 (2004); in diabetic nephropathy: A. Achour et al., J. Nephrol. 18, 568 (2005).
Therap-Cat: Antithrombotic; in treatment of chronic leg ulcers and diabetic nephropathy.
Keywords: Antithrombotic.
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Sulodexide
Systematic (IUPAC) name
Glucurono-2-amino-2-deoxyglucoglucan sulfate
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Routes Oral, Subcutaneous, Intravenous, Intramuscular
Identifiers
CAS number 57821-29-1 YesY
ATC code B01AB11
DrugBank DB06271
KEGG D08547 YesY
Chemical data
Formula  ?
 YesY (what is this?)  (verify)

Sulodexide is a highly purified mixture of glycosaminoglycans composed of low molecular weight heparin (80%) and dermatan sulfate (20%).