Sulthiame

Title: Sulthiame
CAS Registry Number: 61-56-3
CAS Name: 4-(Tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide S,S-dioxide
Additional Names: N-(4¢-sulfamylphenyl)-1,4-butanesultam; tetrahydro-2-(p-sulfamoylphenyl)-1,2-thiazine 1,1-dioxide; 2-(p-aminosulfonylphenyl)tetrahydro-1,2-thiazine dioxide; 1-(p-amidosulfonylphenyl)-2-thiapiperidine 2,2-dioxide; N-(p-aminosulfonylphenyl)-1,4-butanesultam
Trademarks: Elisal (Specia); Ospolot (Bayer); Trolone (3M Pharma)
Molecular Formula: C10H14N2O4S2
Molecular Weight: 290.36
Percent Composition: C 41.36%, H 4.86%, N 9.65%, O 22.04%, S 22.09%
Literature References: Prepn of this type of compd: Helferich, Behnisch, US 2916489 (1959 to Schenley).
Properties: Crystalline powder, mp 180-182°. Practically insol in cold water. Partly sol in boiling water; slightly sol in alcohol, acids; readily sol in alkalies.
Melting point: mp 180-182°
Therap-Cat: Anticonvulsant.
Keywords: Anticonvulsant.
Sultopride Sultosilic Acid Sultroponium Sumatrol Sumbul

Sultiame
Sultiame.svg
Systematic (IUPAC) name
4-(1,1-dioxothiazinan-2-yl)benzenesulfonamide
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. D (AU) D (US)
Legal status POM (UK) -only (US)
Routes Oral
Pharmacokinetic data
Bioavailability 100% (oral)
Protein binding 29%
Metabolism Hepatic secretion
Half-life 24 hours
Excretion Fecal (10%) and renal (90%)
Identifiers
CAS number 61-56-3 N
ATC code N03AX03
PubChem CID 5356
DrugBank DB08329
ChemSpider 5163 YesY
UNII I00Q766CZ2 YesY
KEGG D01787 YesY
ChEMBL CHEMBL328560 YesY
Chemical data
Formula C10H14N2O4S2 
Mol. mass 290.0395 g/mol
 N (what is this?)  (verify)

Sultiame (rINN, also known as sulthiame) is a sulfonamide and inhibitor of the enzyme carbonic anhydrase. It is used as an anticonvulsant.