Sultosilic Acid

Title: Sultosilic Acid
CAS Registry Number: 57775-26-5
CAS Name: 2-Hydroxy-5-[[(4-methylphenyl)sulfonyl]oxy]benzenesulfonic acid
Additional Names: 2-hydroxy-5-tosyloxybenzenesulfonic acid; 2,5-dihydroxybenzenesulfonic acid 5-p-toluenesulfonate
Molecular Formula: C13H12O7S2
Molecular Weight: 344.36
Percent Composition: C 45.34%, H 3.51%, O 32.52%, S 18.62%
Literature References: Prepn: NL 7305916 (1973 to Lab. del Esteve); J. Esteve et al., Eur. J. Med. Chem. 11, 43 (1976); of piperazine salt: A. Esteve-Subirana, US 3954767 (1976). Toxicology: L. Rodriguez et al., Arch. Farmacol. Toxicol. 5, 281 (1979). Metabolism: S. G. Wood et al., Xenobiotica 12, 165 (1982). Clinical evaluation: H. Vinazzer, J. C. Farine, Atherosclerosis 49, 109 (1983). HPLC determn and pharmacokinetics: R. Roser et al., Eur. J. Drug Metab. Pharmacokinet. 11, 1 (1986).
Derivative Type: Piperazine salt
CAS Registry Number: 57775-27-6
Additional Names: Diethylenediamine sultosylate; piperazine sultosylate
Manufacturers' Codes: A-585
Trademarks: Mimedran (Esteve)
Molecular Formula: C13H12O7S2.C4H10N2
Molecular Weight: 430.50
Percent Composition: C 47.43%, H 5.15%, O 26.02%, S 14.90%, N 6.51%
Properties: Crystals from ethanol, mp 174°. LD50 i.p. in beagles, male rats, female rats: 605, 833.6, 1272 mg/kg; orally in rats: >11 g/kg (Rodriguez).
Melting point: mp 174°
Toxicity data: LD50 i.p. in beagles, male rats, female rats: 605, 833.6, 1272 mg/kg; orally in rats: >11 g/kg (Rodriguez)
Therap-Cat: Antilipemic.
Keywords: Antilipemic.
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