Survivin

Title: Survivin
Literature References: Mammalian apoptosis inhibitor; member of the IAP (inhibitor of apopotosis protein) family. Selectively overexpressed in common human cancers and correlates with unfavorable prognosis. Also present in embryonic cells but not detectable in normal differentiated tissues. Cytoplasmic, 142 residue protein; mol wt ~16.5 kDa. Expressed during mitosis in a cell cycle-dependent manner and localized to the mitotic spindle. Identification in human cancers: G. Ambrosini et al., Nat. Med. 3, 917 (1997). Developmentally regulated expression in fetal tissue: C. Adida et al., Am. J. Pathol. 152, 43 (1998). Mechanism of action study: F. Li et al., Nature 396, 580 (1998). Crystal structure of murine: S. W. Muchmore et al., Mol. Cell 6, 173 (2000); of human: L. Chantalat et al., ibid. 183; M. A. Verdecia et al., Nat. Struct. Biol. 7, 602 (2000). Determn in urine and clinical use in diagnosis of bladder cancer: S. D. Smith et al., J. Am. Med. Assoc. 285, 324 (2001).
Suxethonium Bromide Suxibuzone Swertiamarin Sydnones sym-Dichloroethyl Ether

Baculoviral IAP repeat containing 5

PDB rendering based on 1e31.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols BIRC5 (; API4; EPR-1)
External IDs OMIM: 603352 MGI: 1203517 HomoloGene: 37450 ChEMBL: 5989 GeneCards: BIRC5 Gene
RNA expression pattern
PBB GE BIRC5 202095 s at tn.png
PBB GE BIRC5 202094 at tn.png
PBB GE BIRC5 210334 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 332 11799
Ensembl ENSG00000089685 ENSMUSG00000017716
UniProt O15392 O70201
RefSeq (mRNA) NM_001012270 NM_001012272
RefSeq (protein) NP_001012270 NP_001012273
Location (UCSC) Chr 17:
76.21 – 76.22 Mb
Chr 11:
117.85 – 117.86 Mb
PubMed search [1] [2]

Survivin, also called baculoviral inhibitor of apoptosis repeat-containing 5 or BIRC5, is a protein that, in humans, is encoded by the BIRC5 gene.[1][2] NCBI Reference Sequence: NG_029069.1

Survivin is a member of the inhibitor of apoptosis (IAP) family. The survivin protein functions to inhibit caspase activation, thereby leading to negative regulation of apoptosis or programmed cell death. This has been shown by disruption of survivin induction pathways leading to increase in apoptosis and decrease in tumour growth. The survivin protein is expressed highly in most human tumours and fetal tissue, but is completely absent in terminally differentiated cells.[3] These data suggest survivin might provide a new target for cancer therapy that would discrimnate between transformed and normal cells. Survivin expression is also highly regulated by the cell cycle and is only expressed in the G2-M phase. It is known that survivin localizes to the mitotic spindle by interaction with tubulin during mitosis and may play a contributing role in regulating mitosis. The molecular mechanisms of survivin regulation are still not well understood, but regulation of survivin seems to be linked to the p53 protein. It also is a direct target gene of the Wnt pathway and is upregulated by beta-catenin.[4]