Title: TSQ
CAS Registry Number: 109628-27-5
CAS Name: N-(6-Methoxy-8-quinolinyl)-4-methylbenzenesulfonamide
Additional Names: 6-methoxy-8-(p-toluenesulfonyl)aminoquinoline
Molecular Formula: C17H16N2O3S
Molecular Weight: 328.39
Percent Composition: C 62.18%, H 4.91%, N 8.53%, O 14.62%, S 9.76%
Literature References: Fluorescent membrane permeant probe selective for Zn2+ in the presence of Ca2+ and Mg2+. Prepn: G. B. Bachman et al., J. Org. Chem. 15, 1278 (1950). Atomic absoportion determn of Zn2+ to picomole levels in biological systems: J. G. Reyes et al., Biol. Res. 27, 49 (1994). Structure/mechanism analysis: M. S. Nasir et al., J. Biol. Inorg. Chem. 4, 775 (1999). Visualization of reactive zinc in the brain: C. J. Frederickson et al., J. Neurosci. Methods 20, 91 (1987); in extracellular areas of CNS: A. A. Larson et al., Pain 86, 177 (2000); in apoptosis: G. R. Sauer et al., J. Cell Biochem. 88, 954 (2003).
Properties: White crystalline solid from ethanol, mp 133-134°.
Melting point: mp 133-134°
Use: Determn of extracellular and intracellular Zn2+ levels in biological systems.
Tsuduranine Tuaminoheptane Tuberactinomycin Tubercidin Tuberculin

CAS number 109628-27-5
PubChem 130606
ChemSpider 115530 YesY
Jmol-3D images Image 1
Molecular formula C17H16N2O3S
Molar mass 328.39 g mol−1
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

6-Methoxy-(8-p-toluenesulfonamido)quinoline (TSQ) is one of the most efficient fluorescent stains for zinc(II). It was introduced by Russian biochemists Toroptsev and Eshchenko in the early 1970s. The popularity of TSQ as physiological stain rose after seminal works by Christopher Frederickson two decades later.[1] TSQ forms a 2:1 (ligand-metal) complex with zinc and emits blue light upon excitation at 365 nanometers. TSQ has been extensively applied for determination of extracellular or intracellular levels of Zn2+ in biological systems, also to study Zn2+ in mossy fibers of the hippocampus.