Title: Troxipide
CAS Registry Number: 99777-81-8
CAS Name: 3,4,5-Trimethoxy-N-3-piperidinylbenzamide
Additional Names: 3-(3,4,5-trimethoxybenzamido)piperidine
Manufacturers' Codes: KU-54
Trademarks: Aplace (Kyorin)
Molecular Formula: C15H22N2O4
Molecular Weight: 294.35
Percent Composition: C 61.21%, H 7.53%, N 9.52%, O 21.74%
Literature References: Prepn: BE 736840; T. Irikura et al., US 3647805 (1969, 1972 both to Kyorin). Anti-ulcer activity: T. Irikura, K. Kasuga, J. Med. Chem. 14, 357 (1971). Pharmacokinetics in man: T. Irikura et al., Iyakuhin Kenkyu 12, 971 (1981), C.A. 96, 79377s (1982). Effect on gastric mucosa in rats: Y. Abe et al., Nippon Yakurigaku Zasshi 83, 317 (1984), C.A. 101, 456g (1984); on glucosamine synthetase: Y. Abe et al., Oyo Yakuri 27, 521 (1984), C.A. 101, 17001c (1984). Metabolism in rats: K. Tagaki et al., ibid. 1151, C.A. 101, 103555t (1984); K. Tagaki, K. Endo, ibid. 1167, C.A. 101, 103556u (1984). Toxicity: T. Irikura et al., Kiso to Rinsho 12, 3422 (1978).
Properties: Needles from acetonitrile, mp 179-181.5°. Sol in ethanol. LD50 in male, female rats, male, female mice (mg/kg): 500, 2100, 2200, 2000 orally; >4150, >4150, 1600, 1550 s.c.; 340, 340, 300, 305 i.p. (Irikura, 1978).
Melting point: mp 179-181.5°
Toxicity data: LD50 in male, female rats, male, female mice (mg/kg): 500, 2100, 2200, 2000 orally; >4150, >4150, 1600, 1550 s.c.; 340, 340, 300, 305 i.p.
Derivative Type: Hydrochloride hemihydrate
Molecular Formula: C15H22N2O4.HCl.½H2O
Molecular Weight: 339.81
Percent Composition: C 53.02%, H 7.12%, N 8.24%, O 21.19%, Cl 10.43%
Properties: Needles from acetonitrile, mp 206-209°. Sol in ethanol.
Melting point: mp 206-209°
Therap-Cat: Antiulcerative.
Keywords: Antiulcerative; Cytoprotectant (Gastric).
Truxillic Acid Trypan Red Tryparsamide Trypsin Tryptamine

Systematic (IUPAC) name
Clinical data
Trade names Troxip (India), Anytoral (Japan), Aplace (Japan), Aplace (South Korea), Defensa (South Korea), Ke Fen Qi (China), Shugi (China), Troxsin (Japan)
AHFS/ International Drug Names
Legal status Prescription only
Routes Oral
Pharmacokinetic data
Bioavailability 99.6%
Half-life 7.5 hours
Excretion Excreted in urine
CAS number 30751-05-4 N
ATC code A02BX11
PubChem CID 5597
KEGG D01306 YesY
Chemical data
Formula C15H22N2O4 
Mol. mass 294.35 g/mol
 N (what is this?)  (verify)

Troxipide is a drug used in the treatment of gastroesophageal reflux disease. Troxipide is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum. Troxipide is currently marketed in Japan (Aplace),[1] China (Shuqi),[2] South Korea (Defensa),[3] and India (Troxip).[4] It is used for the management of gastric ulcers, and amelioration of gastric mucosal lesions in acute gastritis and acute exacerbation of chronic gastritis.