Tuberculin

Title: Tuberculin
Literature References: A filtrate from triturated Mycobacteria tuberculosis. Old Tuberculin is the culture filtrate prepd by boiling and then filtering the M. tuberculosis culture. Purified protein derivative is a more refined tuberculin prepd by precipitating the culture filtrate with ammonium sulfate. Purification and dermal reactivity: F. B. Seibert, J. T. Glenn, Am. Rev. Tuberc. 44, 9 (1941). Review of tuberculin skin test: G. W. Comstock et al., Am. Rev. Respir. Dis. 124, 356 (1981).
Derivative Type: Purified Protein Derivative
CAS Registry Number: 92129-86-7
Additional Names: PPD
Trademarks: Aplisol (Parke-Davis); Tubersol (Sanofi Pasteur)
Therap-Cat: Diagnostic aid (tuberculosis).
Keywords: Diagnostic Aid.
Tuberin Tubulin Tuftsin Tulathromycin Tulobuterol

Clinical data
AHFS/Drugs.com monograph
Pregnancy cat. C (US)
Legal status -only (US)
Routes Intradermal
Identifiers
ATC code V04CF01
Chemical data
Formula  ?

Tuberculin is an extract of Mycobacterium tuberculosis, M. bovis, or M. avium that is used in skin testing in animals and humans to identify a tuberculosis infection.[1][2] Several types of tuberculin have been used for this, of which purified protein derivative (PPD) is the most important. PPD is a poorly defined, complex mixture of antigens. Tests based upon PPD are relatively unspecific since many of its proteins are found in different mycobacterial species.

Tuberculin is an outer membrane protein of Mycobacterium species.