Tulobuterol

Title: Tulobuterol
CAS Registry Number: 41570-61-0
CAS Name: 2-Chloro-a-[[(1,1-dimethylethyl)amino]methyl]benzenemethanol
Additional Names: a-[(tert-butylamino)methyl]-o-chlorobenzyl alcohol
Molecular Formula: C12H18ClNO
Molecular Weight: 227.73
Percent Composition: C 63.29%, H 7.97%, Cl 15.57%, N 6.15%, O 7.03%
Literature References: A b-adrenergic receptor agonist, related structurally to terbutaline, q.v. Prepn: H. Kato, S. Kurata, DE 2244737 (1973 to Hokuriku), C.A. 78, 147538a (1973). Pharmacology: S. Kubo et al., Arzneim.-Forsch. 25, 1028 (1975); eidem, ibid. 27, 1433 (1977); I. Uesaka et al., ibid. 1439. Metabolism: T. Fujiihashi et al., Oyo Yakuri 18, 347 (1979), C.A. 92, 121781 (1980); K. Matsumura et al., Yakugaku Zasshi 101, 198 (1981), C.A. 94, 167404 (1981). Determn of tulobuterol and its metabolites in human urine: eidem, J. Chromatogr. 222, 53 (1981). Toxicological studies: S. Kubo et al., Oyo Yakuri 13, 197, 317 (1977), C.A. 88, 83591-2 (1978).
Properties: Crystals, mp 89-91°. LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975).
Melting point: mp 89-91°
Toxicity data: LD50 in male mice, rats, rabbits (mg/kg): 305, 850, 563 orally; 170, 417, 164 s.c. (Kubo, 1975)
Derivative Type: Hydrochloride
CAS Registry Number: 56776-01-3
Manufacturers' Codes: C-78
Trademarks: Atenos (UCB); Berachin (Tokyo Tanabe); Brelomax (Abbott); Bremax (Abbott); Hokunalin (Hokuriku); Respacal (Bios-Coutelier)
Molecular Formula: C12H18ClNO.HCl
Molecular Weight: 264.19
Percent Composition: C 54.55%, H 7.25%, Cl 26.84%, N 5.30%, O 6.06%
Properties: White crystalline powder, mp 161-163°.
Melting point: mp 161-163°
Therap-Cat: Bronchodilator.
Keywords: ?Adrenergic Agonist; Bronchodilator; Ephedrine Derivatives.
Tumor Necrosis Factor Tung Oil Tungsten Hexafluoride Tungsten Trioxide Tungstic(VI) Acid

Tulobuterol
Tulobuterol.svg
Tulobuterol ball-and-stick.png
Systematic (IUPAC) name
(RS)-2-(tert-butylamino)-1-(2-chlorophenyl)ethanol
Clinical data
AHFS/Drugs.com International Drug Names
Legal status  ?
Routes Inhaled, oral
Identifiers
CAS number 41570-61-0 N
ATC code R03AC11
PubChem CID 5606
ChemSpider 5404 YesY
UNII 591I9SU0F7 YesY
KEGG D02151 YesY
ChEMBL CHEMBL1159717 YesY
Chemical data
Formula C12H18ClNO 
Mol. mass 227.730 g/mol
 N (what is this?)  (verify)

Tulobuterol (INN) is a long-acting beta2-adrenergic receptor agonist, marketed in Japan as a transdermal patch under the name Hokunalin tape (ホクナリンテープ).[1]