Tymazoline

Title: Tymazoline
CAS Registry Number: 24243-97-8
CAS Name: 4,5-Dihydro-2-[[5-methyl-2-(1-methylethyl)phenoxy]methyl]-1H-imidazole
Additional Names: 2-[(thymyloxy)methyl]-2-imidazoline; 2-(thymyloxymethyl)glyoxalidine; 2-[(p-mentha-1,3,5-trien-2-yloxy)methyl]-2-imidazoline
Molecular Formula: C14H20N2O
Molecular Weight: 232.32
Percent Composition: C 72.38%, H 8.68%, N 12.06%, O 6.89%
Literature References: Prepd from an alkyl thymyloxyacetimidate and ethylenediamine: Sonn, US 2149473 (1939 to Ciba); Djerassi, Scholz, J. Am. Chem. Soc. 69, 1688 (1947). Pharmacology: Pham-Huu-Chanh et al., Therapie 24, 797 (1969).
Derivative Type: Hydrochloride
Trademarks: Pernazene (Synthelabo)
Molecular Formula: C14H20N2O.HCl
Molecular Weight: 268.78
Percent Composition: C 62.56%, H 7.88%, N 10.42%, O 5.95%, Cl 13.19%
Properties: Crystals, mp 215-217° (Sonn); from water or methyl ethyl ketone + ethanol, mp 223.5-225° (Djerassi, Scholz).
Melting point: mp 215-217° (Sonn); mp 223.5-225° (Djerassi, Scholz)
Therap-Cat: Nasal decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.
Tyramine Tyrocidine Tyropanoate Sodium Tyrosinase Tyrosine

Tymazoline
Tymazoline.png
Systematic (IUPAC) name
2-[(5-methyl-2-propan-2-ylphenoxy)methyl]-4,5-dihydro-1H-imidazole
Clinical data
Trade names Thymazen
AHFS/Drugs.com International Drug Names
Legal status  ?
Routes Nasal
Identifiers
CAS number 24243-97-8 N
ATC code R01AA13
PubChem CID 34154
DrugBank DB08803
ChemSpider 31478 YesY
UNII U993RH5585 YesY
KEGG D07373 N
Chemical data
Formula C14H20N2O 
Mol. mass 232.321 g/mol
 N (what is this?)  (verify)

Tymazoline (trade name Thymazen in Poland) is a nasal decongestant that can be used to treat rhinitis. It acts as an antihistaminic and sympathomimetic, reducing swelling, inflammation and mucosal secretions.[1][2]