|Jmol-3D images||Image 1|
|Molar mass||470.60 g mol−1|
|Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)|
Withaferin A is a steroidal lactone which binds to and inhibits vimentin. It was first isolated from Winter cherry (Withania somnifera). and is the first member of the withanolides to be discovered. Withaferin A is a potent inhibitor of angiogenesis (the formation of new blood vessels). Withaferin A inhibits both NF-κB and Sp1 Transcription factor activity. Withaferin A also down regulates VEGF gene expression and can affect calcium signalling.