Title: Xipamide
CAS Registry Number: 14293-44-8
CAS Name: 4-Chloro-5-sulfamoyl-2¢,6¢-salicyloxylidide
Additional Names: 4-chloro-2¢,6¢-dimethyl-5-sulfamoylsalicylanilide; 4-chloro-5-sulfamylsalicyloyl-2¢,6¢-dimethylanilide
Manufacturers' Codes: Bei-1293
Trademarks: Aquaphor (Lilly); Chronexan (Viatris); Diurexan (Viatris); Lumitens (Solvay)
Molecular Formula: C15H15ClN2O4S
Molecular Weight: 354.81
Percent Composition: C 50.78%, H 4.26%, Cl 9.99%, N 7.90%, O 18.04%, S 9.04%
Literature References: Salicylic acid derivative. Prepn: NL 6607680; Liebenow, US 3567777 (1966, 1970 both to P. Beiersdorf). Clinical studies: O. Hammer, U. Dembowski, Med. Klin. 64, 1862 (1969); R. Fischer, A. Lenhartz, Med. Welt 1970, 270. Review of pharmacology and therapeutic efficacy: B. N. C. Prichard, R. N. Brogden, Drugs 30, 313-332 (1985).
Properties: Crystals from methanol-water, mp 256°.
Melting point: mp 256°
Therap-Cat: Diuretic; antihypertensive.
Keywords: Antihypertensive; Sulfonamide Derivatives; Diuretic; Sulfonamide Derivatives.
Xylazine Xylene Xylenol Xylenol Blue Xylidine

Xipamide balls.png
Systematic (IUPAC) name
Clinical data
AHFS/Drugs.com International Drug Names
Pregnancy cat. contraindication
Legal status Prescription only
Routes oral
Pharmacokinetic data
Bioavailability 95%
Protein binding 98%
Metabolism glucuronide (30%)
Half-life 5.8 to 8.2 hours
Excretion renal (1/3) and biliary (2/3)
CAS number 14293-44-8 YesY
ATC code C03BA10
PubChem CID 26618
ChemSpider 24795 N
KEGG D06341 YesY
Chemical data
Formula C15H15ClN2O4S 
Mol. mass 354.80 g/mol
 N (what is this?)  (verify)

Xipamide is a sulfonamide diuretic drug marketed by Eli Lilly under the trade names Aquaphor (in Germany) and Aquaphoril (in Austria). It is used for the treatment of oedema and hypertension.