Xylometazoline

Title: Xylometazoline
CAS Registry Number: 526-36-3
CAS Name: 2-[[4-(1,1-Dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole
Additional Names: 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazoline
Molecular Formula: C16H24N2
Molecular Weight: 244.38
Percent Composition: C 78.64%, H 9.90%, N 11.46%
Literature References: a-Adrenergic agonist; topical vasoconstrictor. Prepn: Hüni, US 2868802 (1959 to Ciba). Pharmacology: S. Morimoto, H. Tanaka, Osaka-shiritsu Daigaku Igaku Zasshi 18, 211 (1969), C.A. 72, 20437n (1970). Comprehensive description: Y. Golander, W. J. DeWitte, Anal. Profiles Drug Subs. 14, 135-156 (1985). GC determn in plasma and urine: A. Sioufi et al., J. Chromatogr. 487, 81 (1989). Clinical trial in allergic rhinitis: M. Fradis et al., J. Laryngol. Otol. 101, 666 (1987); in nasal surgery: J. P. Campbell et al., Otolaryngol. Head Neck Surg. 107, 697 (1992).
Properties: mp 131-133°.
Melting point: mp 131-133°
Derivative Type: Hydrochloride
CAS Registry Number: 1218-35-5
Trademarks: Novorin (Polfa); Olynth (Pfizer); Otrivine (Novartis); Xymelin (Nycomed)
Molecular Formula: C16H24N2.HCl
Molecular Weight: 280.84
Percent Composition: C 68.43%, H 8.97%, N 9.97%, Cl 12.62%
Properties: Soly in water: up to 3%; also sol in methanol, ethanol. Practically insol in ether, benzene.
Therap-Cat: Decongestant.
Keywords: a-Adrenergic Agonist; Decongestant.
Xylose Xylulose Xylyl Bromide Xylyl Chloride Yam, Mexican

Xylometazoline
Xylometazoline Structural Formulae V 2.png
Xylometazoline ball-and-stick animation.gif
Systematic (IUPAC) name
2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-
4,5-dihydro-1H-imidazole
Clinical data
Trade names Otrivin
AHFS/Drugs.com Micromedex Detailed Consumer Information
Pregnancy cat. C
Legal status Not known
Routes Intranasal spray or drops, oral (capsules)
Pharmacokinetic data
Half-life >10 seconds
Excretion Urinary
Identifiers
CAS number 526-36-3 N
ATC code R01AA07 S01GA03
PubChem CID 5709
IUPHAR ligand 517
DrugBank DB06694
ChemSpider 5507 YesY
UNII WPY40FTH8K YesY
KEGG D08684 YesY
ChEMBL CHEMBL312448 YesY
Chemical data
Formula C16H24N2 
Mol. mass 244.37516 g/mol
 N (what is this?)  (verify)

Xylometazoline (also known as xylomethazoline) is a drug which is used as a topical nasal decongestant.[1] It is applied directly into the nose, either as a spray or as drops.

Xylometazoline is marketed under many brand names (see below), with the typical adult solution strength being 0.1% w/v xylometazoline, and the dose for children under 12 being 0.05%.[citation needed]

It should not be used for too long a period of time, or rebound effect may occur after discontinuation (see: Rhinitis medicamentosa).