Zinostatin

Title: Zinostatin
CAS Registry Number: 9014-02-2
CAS Name: Neocarzinostatin
Additional Names: neocarcinostatin; NCS
Manufacturers' Codes: NSC-69856
Literature References: An antitumor acidic antibiotic consisting of 2 components: a protein of mol wt 10,700 containing 109 amino acid residues of 18 kinds and a labile non-protein chromophore which possesses the full biological activity of NCS. Isoln from the culture filtrate of Streptomyces carcinostaticus var. F-41: N. Ishida et al., J. Antibiot. 18A, 68 (1965). Characterization: H. Maeda et al., ibid. 19A, 253 (1966). Prodn: N. Ishida et al., US 3334022 (1967 to Empire Corp.). Amino acid sequence: J. Meienhofer et al., Science 178, 875 (1972). Review of protein structural studies: eidem, Progress in Peptide Research vol. II, S. Lande, Ed. (Gordon and Breach, New York, 1972) pp 295-306. Spectral characterization and separation of the chromophore: M. A. Napier et al., Biochem. Biophys. Res. Commun. 89, 635 (1979). Partial structure of the chromophore: G. Albers-Schönberg et al., ibid. 95, 1351 (1980). Roles of chromophore and apo-protein in biological activity: L. S. Kappen et al., Proc. Natl. Acad. Sci. USA 77, 1970 (1980). Molecular basis of action: I. H. Goldberg et al., Mol. Biol. Biochem. Biophys. 32, 308 (1980). Absorption, distribution, excretion: K. Toriyama et al., Jpn. J. Antibiot. 28, 64 (1975). Review of pharmacology: T. A. Beerman et al., in Advances in Enzyme Regulation vol. 14, G. Weber, Ed. (Pergamon Press, New York, 1976) pp 207-228.
Properties: White powder, mp 260° (dec). uv max (water): 278 nm (E1%1cm 15). Isoelectric pt: pH 3.26 [Jpn. Med. Gaz. 14(3), 11 (1977)]. Sol in water. Insol in most common org solvents. See M. Kohno et al., Jpn. J. Antibiot. 27, 707 (1974) for stability of aq solns. LD50 in mice (mg/kg): 1050 orally, 0.96 i.v. (Toriyama).
Melting point: mp 260° (dec)
Absorption maximum: uv max (water): 278 nm (E1%1cm 15)
Toxicity data: LD50 in mice (mg/kg): 1050 orally, 0.96 i.v. (Toriyama)
Therap-Cat: Antineoplastic.
Keywords: Antineoplastic; Antibiotics and Analogs.
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